1w9b: Difference between revisions

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-{{Seed}}
-[[Image:1w9b.png|left|200px]]
-<!--
+==S. alba myrosinase in complex with carba-glucotropaeolin==
-The line below this paragraph, containing "STRUCTURE_1w9b", creates the "Structure Box" on the page.
+<StructureSection load='1w9b' size='340' side='right'caption='[[1w9b]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1w9b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sinapis_alba Sinapis alba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W9B FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CGT:CARBA-GLUCOTROPAEOLIN'>CGT</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_1w9b|  PDB=1w9b  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9b OCA], [https://pdbe.org/1w9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w9b RCSB], [https://www.ebi.ac.uk/pdbsum/1w9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w9b ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MYRA_SINAL MYRA_SINAL] Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w9/1w9b_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w9b ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Myrosinase, a thioglucoside glucohydrolase, is the only enzyme able to hydrolyse glucosinolates, a unique family of molecules bearing an anomeric O-sulfated thiohydroximate function. Non-hydrolysable myrosinase inhibitors have been devised and studied for their biological interaction. Diverse modifications of the O-sulfate moiety did not result in a significant inhibitory effect, whereas replacing the D-glucopyrano residue by its carba-analogue allowed inhibition to take place. X-Ray experiments carried out after soaking allowed for the first time inclusion of a non-hydrolysable inhibitor inside the enzymatic pocket. Structural tuning of the aglycon part in its pocket is being used as a guide for the development of simplified and more potent inhibitors.
-===S. ALBA MYROSINASE IN COMPLEX WITH CARBA-GLUCOTROPAEOLIN===
+The glucosinolate-myrosinase system. New insights into enzyme-substrate interactions by use of simplified inhibitors.,Bourderioux A, Lefoix M, Gueyrard D, Tatibouet A, Cottaz S, Arzt S, Burmeister WP, Rollin P Org Biomol Chem. 2005 May 21;3(10):1872-9. Epub 2005 Apr 14. PMID:15889170<ref>PMID:15889170</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_15889170}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1w9b" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 15889170 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_15889170}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-W9B is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sinapis_alba Sinapis alba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9B OCA].
-==Reference==
-<ref group="xtra">PMID:15889170</ref><references group="xtra"/>
 [[Category: Sinapis alba]]
-[[Category: Thioglucosidase]]
+[[Category: Arzt S]]
-[[Category: Arzt, S.]]
+[[Category: Bourderioux A]]
-[[Category: Bourderioux, A.]]
+[[Category: Burmeister WP]]
-[[Category: Burmeister, W P.]]
+[[Category: Cottaz S]]
-[[Category: Cottaz, S.]]
+[[Category: Gueyrard D]]
-[[Category: Gueyrard, D.]]
+[[Category: Lefoix M]]
-[[Category: Lefoix, M.]]
+[[Category: Rollin P]]
-[[Category: Rollin, P.]]
+[[Category: Tatibouet A]]
-[[Category: Tatibouet, A.]]
-[[Category: Glucotropaeolin]]
-[[Category: Glusosinolate]]
-[[Category: Hydrolase]]
-[[Category: Myrosinase]]
-[[Category: Thio-glucoside]]
-[[Category: Thioglucosidase]]
-[[Category: Thioglycosidase]]
-[[Category: Thiohydroximate]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:23:55 2009''