1vyt: Difference between revisions

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 <StructureSection load='1vyt' size='340' side='right'caption='[[1vyt]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1vyt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VYT FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1vyt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VYT FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vyu|1vyu]], [[1vyv|1vyv]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyt OCA], [http://pdbe.org/1vyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vyt RCSB], [http://www.ebi.ac.uk/pdbsum/1vyt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vyt ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyt OCA], [https://pdbe.org/1vyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vyt RCSB], [https://www.ebi.ac.uk/pdbsum/1vyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vyt ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CACB3_RAT CACB3_RAT]] The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. [[http://www.uniprot.org/uniprot/CAC1C_RAT CAC1C_RAT]] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.
+[https://www.uniprot.org/uniprot/CACB3_RAT CACB3_RAT] The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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    <jmolCheckbox>
      <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/1vyt_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 35: / Line 35: @@
 __TOC__
 </StructureSection>
-[[Category: Buffalo rat]]
 [[Category: Large Structures]]
-[[Category: Chen, Y H]]
+[[Category: Rattus norvegicus]]
-[[Category: Fitzmaurice, A]]
+[[Category: Chen Y-H]]
-[[Category: He, L L]]
+[[Category: Fitzmaurice A]]
-[[Category: Li, M H]]
+[[Category: He L-L]]
-[[Category: Tong, L]]
+[[Category: Li M-H]]
-[[Category: Yamada, Y]]
+[[Category: Tong L]]
-[[Category: Yang, J]]
+[[Category: Yamada Y]]
-[[Category: Yang, S]]
+[[Category: Yang J]]
-[[Category: Zhang, H]]
+[[Category: Yang S]]
-[[Category: Zhang, Y]]
+[[Category: Zhang H]]
-[[Category: Aid doamin]]
+[[Category: Zhang Y]]
-[[Category: Calcium channel beta subunit]]
-[[Category: Ion transport]]
-[[Category: Ion transport-complex]]
-[[Category: Ionic channel]]
-[[Category: Sh3 domain]]
-[[Category: Transport protein]]
-[[Category: Voltage-gated channel]]