1spp: Difference between revisions

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-[[Image:1spp.png|left|200px]]
-{{STRUCTURE_1spp|  PDB=1spp  |  SCENE=  }}
+==THE CRYSTAL STRUCTURES OF TWO MEMBERS OF THE SPERMADHESIN FAMILY REVEAL THE FOLDING OF THE CUB DOMAIN==
+<StructureSection load='1spp' size='340' side='right'caption='[[1spp]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1spp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SPP FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1spp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1spp OCA], [https://pdbe.org/1spp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1spp RCSB], [https://www.ebi.ac.uk/pdbsum/1spp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1spp ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PSP1_PIG PSP1_PIG] Not yet identified, major porcine seminal plasma protein. Can bind soybean trypsin inhibitor after deglycosylation.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sp/1spp_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1spp ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Spermadhesins, 12,000-14,000 M(r) mammalian proteins, include lectins involved in sperm-egg binding and display a single CUB domain architecture. We report the crystal structures of porcine seminal plasma PSP-I/PSP-II, a heterodimer of two glycosylated spermadhesins, and bovine aSFP at 2.4 A and 1.9 A resolution respectively.
-===THE CRYSTAL STRUCTURES OF TWO MEMBERS OF THE SPERMADHESIN FAMILY REVEAL THE FOLDING OF THE CUB DOMAIN===
+The crystal structures of two spermadhesins reveal the CUB domain fold.,Romero A, Romao MJ, Varela PF, Kolln I, Dias JM, Carvalho AL, Sanz L, Topfer-Petersen E, Calvete JJ Nat Struct Biol. 1997 Oct;4(10):783-8. PMID:9334740<ref>PMID:9334740</ref>
-{{ABSTRACT_PUBMED_9334740}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 1spp" style="background-color:#fffaf0;"></div>
-[[1spp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SPP OCA].
+== References ==
+<references/>
-==Reference==
+__TOC__
-<ref group="xtra">PMID:009334740</ref><references group="xtra"/>
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Sus scrofa]]
-[[Category: Calvete, J J.]]
+[[Category: Calvete JJ]]
-[[Category: Carvalho, A L.]]
+[[Category: Carvalho AL]]
-[[Category: Dias, J M.]]
+[[Category: Dias JM]]
-[[Category: Kolln, I.]]
+[[Category: Kolln I]]
-[[Category: Romao, M J.]]
+[[Category: Romao MJ]]
-[[Category: Romero, A.]]
+[[Category: Romero A]]
-[[Category: Sanz, L.]]
+[[Category: Sanz L]]
-[[Category: Topfer-Petersen, E.]]
+[[Category: Topfer-Petersen E]]
-[[Category: Varela, P F.]]
+[[Category: Varela PF]]
-[[Category: Cub domain architecture]]
-[[Category: Seminal plasma protein]]
-[[Category: Spermadhesin]]