1mzp: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:1mzp.png|left|200px]]
-<!--
+==Structure of the L1 protuberance in the ribosome==
-The line below this paragraph, containing "STRUCTURE_1mzp", creates the "Structure Box" on the page.
+<StructureSection load='1mzp' size='340' side='right'caption='[[1mzp]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1mzp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MZP FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-{{STRUCTURE_1mzp|  PDB=1mzp  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzp OCA], [https://pdbe.org/1mzp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mzp RCSB], [https://www.ebi.ac.uk/pdbsum/1mzp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mzp ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RL1_SULAC RL1_SULAC] Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.  Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mz/1mzp_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mzp ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The L1 protuberance of the 50S ribosomal subunit is implicated in the release/disposal of deacylated tRNA from the E site. The apparent mobility of this ribosomal region has thus far prevented an accurate determination of its three-dimensional structure within either the 50S subunit or the 70S ribosome. Here we report the crystal structure at 2.65 A resolution of ribosomal protein L1 from Sulfolobus acidocaldarius in complex with a specific 55-nucleotide fragment of 23S rRNA from Thermus thermophilus. This structure fills a major gap in current models of the 50S ribosomal subunit. The conformations of L1 and of the rRNA fragment differ dramatically from those within the crystallographic model of the T. thermophilus 70S ribosome. Incorporation of the L1-rRNA complex into the structural models of the T. thermophilus 70S ribosome and the Deinococcus radiodurans 50S subunit gives a reliable representation of most of the L1 protuberance within the ribosome.
-===Structure of the L1 protuberance in the ribosome===
+Structure of the L1 protuberance in the ribosome.,Nikulin A, Eliseikina I, Tishchenko S, Nevskaya N, Davydova N, Platonova O, Piendl W, Selmer M, Liljas A, Drygin D, Zimmermann R, Garber M, Nikonov S Nat Struct Biol. 2003 Feb;10(2):104-8. PMID:12514741<ref>PMID:12514741</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1mzp" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_12514741}}, adds the Publication Abstract to the page
+*[[Ribosomal protein L1|Ribosomal protein L1]]
-(as it appears on PubMed at http://www.pubmed.gov), where 12514741 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_12514741}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-MZP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZP OCA].
-==Reference==
-Structure of the L1 protuberance in the ribosome., Nikulin A, Eliseikina I, Tishchenko S, Nevskaya N, Davydova N, Platonova O, Piendl W, Selmer M, Liljas A, Drygin D, Zimmermann R, Garber M, Nikonov S, Nat Struct Biol. 2003 Feb;10(2):104-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12514741 12514741]
-[[Category: Single protein]]
 [[Category: Sulfolobus acidocaldarius]]
-[[Category: Davydova, N.]]
+[[Category: Davydova N]]
-[[Category: Eliseikina, I.]]
+[[Category: Eliseikina I]]
-[[Category: Garber, M.]]
+[[Category: Garber M]]
-[[Category: Liljas, A.]]
+[[Category: Liljas A]]
-[[Category: Nevskaya, N.]]
+[[Category: Nevskaya N]]
-[[Category: Nikonov, S.]]
+[[Category: Nikonov S]]
-[[Category: Nikulin, A.]]
+[[Category: Nikulin A]]
-[[Category: Piendl, W.]]
+[[Category: Piendl W]]
-[[Category: Platonova, O.]]
+[[Category: Platonova O]]
-[[Category: Selmer, M.]]
+[[Category: Selmer M]]
-[[Category: Tishchenko, S.]]
+[[Category: Tishchenko S]]
-[[Category: Zimmermann, R.]]
+[[Category: Zimmermann R]]
-[[Category: Ribosomal protein]]
-[[Category: Ribosome]]
-[[Category: Rna-protein complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:30:39 2008''