1hq8: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:1hq8.png|left|200px]]
-<!--
+==CRYSTAL STRUCTURE OF THE MURINE NK CELL-ACTIVATING RECEPTOR NKG2D AT 1.95 A==
-The line below this paragraph, containing "STRUCTURE_1hq8", creates the "Structure Box" on the page.
+<StructureSection load='1hq8' size='340' side='right'caption='[[1hq8]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1hq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HQ8 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hq8 OCA], [https://pdbe.org/1hq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1hq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hq8 ProSAT]</span></td></tr>
-{{STRUCTURE_1hq8|  PDB=1hq8  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NKG2D_MOUSE NKG2D_MOUSE] Receptor for RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1. Involved in the immune surveillance exerted by T and B lymphocytes.<ref>PMID:12370332</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/1hq8_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hq8 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+NKG2D, a homodimeric lectin-like receptor, is a unique stimulatory molecule that is found on natural killer cells,T cells and activated macrophages.The natural ligands for murine NKG2D are distant major histocompatibility complex homologs, retinoic acid early transcript (Rae1) and H-60 minor histocompatibility antigen. The crystal structure of the extracellular region of murine NKG2D reveals close homology with other C-type lectin receptors such as CD94, Ly49A, rat MBP-A and CD69. However, the precise mode of dimeric assembly varies among these natural killer receptors, as well as their surface topography and electrostatic properties.The NKG2D structure provides the first structural insights into the role and ligand specificity of this stimulatory receptor in the innate and adaptive immune system.
-===CRYSTAL STRUCTURE OF THE MURINE NK CELL-ACTIVATING RECEPTOR NKG2D AT 1.95 A===
+Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A.,Wolan DW, Teyton L, Rudolph MG, Villmow B, Bauer S, Busch DH, Wilson IA Nat Immunol. 2001 Mar;2(3):248-54. PMID:11224525<ref>PMID:11224525</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1hq8" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_11224525}}, adds the Publication Abstract to the page
+*[[NK cell receptor|NK cell receptor]]
-(as it appears on PubMed at http://www.pubmed.gov), where 11224525 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_11224525}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-HQ8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQ8 OCA].
-==Reference==
-<ref group="xtra">PMID:11224525</ref><references group="xtra"/>
 [[Category: Mus musculus]]
-[[Category: Bauer, S.]]
+[[Category: Bauer S]]
-[[Category: Busch, D H.]]
+[[Category: Busch DH]]
-[[Category: Rudolph, M G.]]
+[[Category: Rudolph MG]]
-[[Category: Teyton, L.]]
+[[Category: Teyton L]]
-[[Category: Villmow, B.]]
+[[Category: Villmow B]]
-[[Category: Wilson, I A.]]
+[[Category: Wilson IA]]
-[[Category: Wolan, D W.]]
+[[Category: Wolan DW]]
-[[Category: Cis-proline]]
-[[Category: Homodimer]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:44:52 2009''