1gml: Difference between revisions

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-{{Seed}}
-[[Image:1gml.png|left|200px]]
-<!--
+==crystal structure of the mouse CCT gamma apical domain (triclinic)==
-The line below this paragraph, containing "STRUCTURE_1gml", creates the "Structure Box" on the page.
+<StructureSection load='1gml' size='340' side='right'caption='[[1gml]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1gml]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GML FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-{{STRUCTURE_1gml|  PDB=1gml  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gml OCA], [https://pdbe.org/1gml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gml RCSB], [https://www.ebi.ac.uk/pdbsum/1gml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gml ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TCPG_MOUSE TCPG_MOUSE] Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.[UniProtKB:P49368]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gm/1gml_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gml ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The chaperonin containing TCP-1 (CCT, also known as TRiC) is the only member of the chaperonin family found in the cytosol of eukaryotes. Like other chaperonins, it assists the folding of newly synthesised proteins. It is, however, unique in its specificity towards only a small subset of non-native proteins. We determined two crystal structures of mouse CCTgamma apical domain at 2.2 A and 2.8 A resolution. They reveal a surface patch facing the inside of the torus that is highly evolutionarily conserved and specific for the CCTgamma apical domain. This putative substrate-binding region consists of predominantly positively charged side-chains. It suggests that the specificity of this apical domain towards its substrate, partially folded tubulin, is conferred by polar and electrostatic interactions. The site and nature of substrate interaction are thus profoundly different between CCT and its eubacterial homologue GroEL, consistent with their different functions in general versus specific protein folding assistance.
-===CRYSTAL STRUCTURE OF THE MOUSE CCT GAMMA APICAL DOMAIN (TRICLINIC)===
+Crystal structure of the CCTgamma apical domain: implications for substrate binding to the eukaryotic cytosolic chaperonin.,Pappenberger G, Wilsher JA, Roe SM, Counsell DJ, Willison KR, Pearl LH J Mol Biol. 2002 May 17;318(5):1367-79. PMID:12083524<ref>PMID:12083524</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1gml" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_12083524}}, adds the Publication Abstract to the page
+*[[Chaperonin 3D structures|Chaperonin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 12083524 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_12083524}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-GML is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GML OCA].
-==Reference==
-Crystal structure of the CCTgamma apical domain: implications for substrate binding to the eukaryotic cytosolic chaperonin., Pappenberger G, Wilsher JA, Roe SM, Counsell DJ, Willison KR, Pearl LH, J Mol Biol. 2002 May 17;318(5):1367-79. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12083524 12083524]
 [[Category: Mus musculus]]
-[[Category: Single protein]]
+[[Category: Pappenberger G]]
-[[Category: Pappenberger, G.]]
+[[Category: Pearl LH]]
-[[Category: Pearl, L H.]]
+[[Category: Roe SM]]
-[[Category: Roe, S M.]]
+[[Category: Willison KR]]
-[[Category: Willison, K R.]]
+[[Category: Wilsher JA]]
-[[Category: Wilsher, J.]]
-[[Category: Actin]]
-[[Category: Chaperone]]
-[[Category: Chaperonin]]
-[[Category: Tubulin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 05:31:16 2008''