1cv9: Difference between revisions

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OCA

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 ==NMR STUDY OF ITAM PEPTIDE SUBSTRATE==
-<StructureSection load='1cv9' size='340' side='right' caption='[[1cv9]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
+<StructureSection load='1cv9' size='340' side='right'caption='[[1cv9]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1cv9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CV9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1cv9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CV9 FirstGlance]. <br>
-</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv9 OCA], [http://pdbe.org/1cv9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cv9 RCSB], [http://www.ebi.ac.uk/pdbsum/1cv9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cv9 ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cv9 OCA], [https://pdbe.org/1cv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cv9 RCSB], [https://www.ebi.ac.uk/pdbsum/1cv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cv9 ProSAT]</span></td></tr>
 </table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CD79A_HUMAN CD79A_HUMAN] Autosomal agammaglobulinemia. The disease is caused by variants affecting the gene represented in this entry. Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for exon 3, have been identified. Both mutations give rise to a truncated protein.
+== Function ==
+[https://www.uniprot.org/uniprot/CD79A_HUMAN CD79A_HUMAN] Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.<ref>PMID:8617796</ref> <ref>PMID:9057631</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </StructureSection>
-[[Category: Gaul, B S]]
+[[Category: Homo sapiens]]
-[[Category: Geahlen, R L]]
+[[Category: Large Structures]]
-[[Category: Harrison, M L]]
+[[Category: Gaul BS]]
-[[Category: Post, C B]]
+[[Category: Geahlen RL]]
-[[Category: Immune system]]
+[[Category: Harrison ML]]
-[[Category: Immunoreceptor tyrosine activation motif]]
+[[Category: Post CB]]
-[[Category: Itam]]
-[[Category: Lyn tyrosine kinase]]
-[[Category: Peptide substate]]