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==SEQUENTIAL 1H,13C AND 15N NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF APOKEDARCIDIN==
==SEQUENTIAL 1H,13C AND 15N NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF APOKEDARCIDIN==
<StructureSection load='1akp' size='340' side='right' caption='[[1akp]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='1akp' size='340' side='right'caption='[[1akp]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1akp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinomycete_atcc_53650 Actinomycete atcc 53650]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AKP FirstGlance]. <br>
<table><tr><td colspan='2'>[[1akp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinomycete_ATCC_53650 Actinomycete ATCC 53650]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AKP FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1akp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1akp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1akp RCSB], [http://www.ebi.ac.uk/pdbsum/1akp PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1akp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1akp OCA], [https://pdbe.org/1akp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1akp RCSB], [https://www.ebi.ac.uk/pdbsum/1akp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1akp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KEDA_ACTSL KEDA_ACTSL] Binds non-covalently to an enediyne chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore cleaves duplex DNA site-specifically in a single-stranded manner. The apoprotein cleaves proteins selectively, in particular highly basic histones, with H1 proteins being cleaved the more readily.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 1akp" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Actinomycete atcc 53650]]
[[Category: Actinomycete ATCC 53650]]
[[Category: Bruccoleri, R E]]
[[Category: Large Structures]]
[[Category: Colson, K L]]
[[Category: Bruccoleri RE]]
[[Category: Constantine, K L]]
[[Category: Colson KL]]
[[Category: Friedrichs, M S]]
[[Category: Constantine KL]]
[[Category: II, B T.Farmer]]
[[Category: Farmer II BT]]
[[Category: Lam, K S]]
[[Category: Friedrichs MS]]
[[Category: Langley, D R]]
[[Category: Lam KS]]
[[Category: Leet, J E]]
[[Category: Langley DR]]
[[Category: Metzler, W J]]
[[Category: Leet JE]]
[[Category: Mueller, L]]
[[Category: Metzler WJ]]
[[Category: Schroeder, D R]]
[[Category: Mueller L]]
[[Category: Tuttle, J]]
[[Category: Schroeder DR]]
[[Category: Wittekind, M]]
[[Category: Tuttle J]]
[[Category: Zein, N]]
[[Category: Wittekind M]]
[[Category: Antibiotic chromoprotein]]
[[Category: Zein N]]

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