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==SEQUENTIAL 1H,13C AND 15N NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF APOKEDARCIDIN== | ==SEQUENTIAL 1H,13C AND 15N NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF APOKEDARCIDIN== | ||
<StructureSection load='1akp' size='340' side='right' caption='[[1akp | <StructureSection load='1akp' size='340' side='right'caption='[[1akp]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1akp]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1akp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinomycete_ATCC_53650 Actinomycete ATCC 53650]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AKP FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1akp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1akp OCA], [https://pdbe.org/1akp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1akp RCSB], [https://www.ebi.ac.uk/pdbsum/1akp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1akp ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/KEDA_ACTSL KEDA_ACTSL] Binds non-covalently to an enediyne chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore cleaves duplex DNA site-specifically in a single-stranded manner. The apoprotein cleaves proteins selectively, in particular highly basic histones, with H1 proteins being cleaved the more readily. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1akp" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Actinomycete | [[Category: Actinomycete ATCC 53650]] | ||
[[Category: Bruccoleri | [[Category: Large Structures]] | ||
[[Category: Colson | [[Category: Bruccoleri RE]] | ||
[[Category: Constantine | [[Category: Colson KL]] | ||
[[Category: | [[Category: Constantine KL]] | ||
[[Category: | [[Category: Farmer II BT]] | ||
[[Category: Lam | [[Category: Friedrichs MS]] | ||
[[Category: Langley | [[Category: Lam KS]] | ||
[[Category: Leet | [[Category: Langley DR]] | ||
[[Category: Metzler | [[Category: Leet JE]] | ||
[[Category: Mueller | [[Category: Metzler WJ]] | ||
[[Category: Schroeder | [[Category: Mueller L]] | ||
[[Category: Tuttle | [[Category: Schroeder DR]] | ||
[[Category: Wittekind | [[Category: Tuttle J]] | ||
[[Category: Zein | [[Category: Wittekind M]] | ||
[[Category: Zein N]] |