6b7z: Difference between revisions
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==Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11 heavy chain and FAB H11 light chain== | ==Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11 heavy chain and FAB H11 light chain== | ||
< | <SX load='6b7z' size='340' side='right' viewer='molstar' caption='[[6b7z]], [[Resolution|resolution]] 6.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6b7z]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B7Z OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6b7z]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B7Z FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b7z OCA], [https://pdbe.org/6b7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b7z RCSB], [https://www.ebi.ac.uk/pdbsum/6b7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b7z ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</ | </SX> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bailey | [[Category: Mus musculus]] | ||
[[Category: Carragher | [[Category: Bailey LJ]] | ||
[[Category: Kossiakoff | [[Category: Carragher B]] | ||
[[Category: Liang | [[Category: Kossiakoff AA]] | ||
[[Category: Potter | [[Category: Liang WG]] | ||
[[Category: Tan | [[Category: Potter SC]] | ||
[[Category: Tang | [[Category: Tan YZ]] | ||
[[Category: Wei | [[Category: Tang WJ]] | ||
[[Category: Zhang | [[Category: Wei H]] | ||
[[Category: Zhang Z]] | |||