5npn: Difference between revisions

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==Refined structure of cytotoxin I==
==Refined structure of cytotoxin I==
<StructureSection load='5npn' size='340' side='right'caption='[[5npn]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='5npn' size='340' side='right'caption='[[5npn]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5npn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NPN FirstGlance]. <br>
<table><tr><td colspan='2'>[[5npn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NPN FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5npn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5npn OCA], [http://pdbe.org/5npn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5npn RCSB], [http://www.ebi.ac.uk/pdbsum/5npn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5npn ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5npn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5npn OCA], [https://pdbe.org/5npn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5npn RCSB], [https://www.ebi.ac.uk/pdbsum/5npn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5npn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/3SA1_NAJOX 3SA1_NAJOX]] This three-finger cytotoxin is a basic protein that interacts and penetrates into the cell membrane, with the tips of all the three loops. Cytotoxins which have a 'Pro-30' (P-type) interacts with membrane stronger that those which have a Ser-28 (S-type). CTI interacts with membrane weaker than CTII.  
[https://www.uniprot.org/uniprot/3SA1_NAJOX 3SA1_NAJOX] This three-finger cytotoxin is a basic protein that interacts and penetrates into the cell membrane, with the tips of all the three loops. Cytotoxins which have a 'Pro-30' (P-type) interacts with membrane stronger that those which have a Ser-28 (S-type). CTI interacts with membrane weaker than CTII.
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Naja oxiana]]
[[Category: Naja oxiana]]
[[Category: Arseniev, A S]]
[[Category: Arseniev AS]]
[[Category: Dubinnyi, M A]]
[[Category: Dubinnyi MA]]
[[Category: Dubovskii, P V]]
[[Category: Dubovskii PV]]
[[Category: Cobra venom]]
[[Category: Cytolytic peptide]]
[[Category: Thre-finger folded protein]]
[[Category: Toxin]]

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