4est: Difference between revisions

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New page: left|200px<br /><applet load="4est" size="450" color="white" frame="true" align="right" spinBox="true" caption="4est, resolution 1.78Å" /> '''CRYSTAL STRUCTURE OF...
 
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[[Image:4est.gif|left|200px]]<br /><applet load="4est" size="450" color="white" frame="true" align="right" spinBox="true"
caption="4est, resolution 1.78&Aring;" />
'''CRYSTAL STRUCTURE OF THE COVALENT COMPLEX FORMED BY A PEPTIDYL ALPHA,ALPHA-DIFLUORO-BETA-KETO AMIDE WITH PORCINE PANCREATIC ELASTASE AT 1.78-ANGSTROMS RESOLUTION'''<br />


==About this Structure==
==CRYSTAL STRUCTURE OF THE COVALENT COMPLEX FORMED BY A PEPTIDYL ALPHA,ALPHA-DIFLUORO-BETA-KETO AMIDE WITH PORCINE PANCREATIC ELASTASE AT 1.78-ANGSTROMS RESOLUTION==
4EST is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with SO4, CA, ACE and FPA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=4EST OCA].
<StructureSection load='4est' size='340' side='right'caption='[[4est]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
[[Category: Pancreatic elastase]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[4est]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EST FirstGlance]. <br>
[[Category: Meyerjunior, E.F.]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
[[Category: Radhakrishnan, R.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FPA:BROMO(DIFLUORO)ACETIC+ACID'>FPA</scene>, <scene name='pdbligand=PEA:2-PHENYLETHYLAMINE'>PEA</scene>, <scene name='pdbligand=PRD_000236:N-acetyl-L-alanyl-N-{(1S)-3,3-difluoro-1-(1-methylethyl)-2,4-dioxo-4-[(2-phenylethyl)amino]butyl}-L-prolinamide'>PRD_000236</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VAI:(2S)-2-AMINO-3-METHYLBUTANE-1,1-DIOL'>VAI</scene></td></tr>
[[Category: Rosenfieldjunior, R.E.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4est FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4est OCA], [https://pdbe.org/4est PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4est RCSB], [https://www.ebi.ac.uk/pdbsum/4est PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4est ProSAT]</span></td></tr>
[[Category: Takahashi, L.H.]]
</table>
[[Category: Trainor, D.A.]]
== Function ==
[[Category: ACE]]
[https://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG] Acts upon elastin.
[[Category: CA]]
== Evolutionary Conservation ==
[[Category: FPA]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: SO4]]
Check<jmol>
[[Category: hydrolase(serine proteinase)]]
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/4est_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4est ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 19:34:30 2007''
==See Also==
*[[Elastase 3D structures|Elastase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Meyerjunior EF]]
[[Category: Radhakrishnan R]]
[[Category: Rosenfieldjunior RE]]
[[Category: Takahashi LH]]
[[Category: Trainor DA]]

Latest revision as of 11:19, 9 October 2024

CRYSTAL STRUCTURE OF THE COVALENT COMPLEX FORMED BY A PEPTIDYL ALPHA,ALPHA-DIFLUORO-BETA-KETO AMIDE WITH PORCINE PANCREATIC ELASTASE AT 1.78-ANGSTROMS RESOLUTIONCRYSTAL STRUCTURE OF THE COVALENT COMPLEX FORMED BY A PEPTIDYL ALPHA,ALPHA-DIFLUORO-BETA-KETO AMIDE WITH PORCINE PANCREATIC ELASTASE AT 1.78-ANGSTROMS RESOLUTION

Structural highlights

4est is a 2 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.78Å
Ligands:, , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CELA1_PIG Acts upon elastin.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

4est, resolution 1.78Å

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