4btt: Difference between revisions

<StructureSection load='4btt' size='340' side='right'caption='[[4btt]], [[Resolution|resolution]] 2.59&Aring;' scene=''>

<table><tr><td colspan='2'>[[4btt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BTT FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=VYR:N-[(S)-1-[5-(5-CHLORO-THIOPHEN-2-YL)-ISOXAZOL-3-YLMETHYL]-2-(4-METHOXY-PIPERIDIN-1-YL)-2-OXO-ETHYL]-2-ETHYL-3-(3-OXO-MORPHOLIN-4-YL)-BENZENESULFONAMIDE'>VYR</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4btt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4btt OCA], [https://pdbe.org/4btt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4btt RCSB], [https://www.ebi.ac.uk/pdbsum/4btt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4btt ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>  

[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

[[Category: Alet N]]

[[Category: Altenburger JM]]

[[Category: Barre G]]

[[Category: Bocskei Z]]

[[Category: Bono F]]

[[Category: Briot C]]

[[Category: Dol F]]

[[Category: Follmann M]]

[[Category: Hasbrand C]]

[[Category: Herault J-P]]

[[Category: Herbert J-M]]

[[Category: Klieber S]]

[[Category: Lassalle G]]

[[Category: Meneyrol J]]

[[Category: Millet L]]

[[Category: Petit F]]

[[Category: Rousseaux T]]

[[Category: Sadoun F]]

[[Category: Schaeffer P]]

[[Category: Schreuder H]]

[[Category: Stehlin-Gaon C]]

[[Category: Wehner V]]