3v6z: Difference between revisions

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-[[Image:3v6z.jpg|left|200px]]
-{{STRUCTURE_3v6z|  PDB=3v6z  |  SCENE=  }}
+==Crystal Structure of Hepatitis B Virus e-antigen==
+<StructureSection load='3v6z' size='340' side='right'caption='[[3v6z]], [[Resolution|resolution]] 3.34&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3v6z]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus Hepatitis B virus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6Z FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.34&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6z OCA], [https://pdbe.org/3v6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6z RCSB], [https://www.ebi.ac.uk/pdbsum/3v6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6z ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q9QMH8_HBV Q9QMH8_HBV]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Chronic hepatitis B virus (HBV) infection afflicts millions worldwide with cirrhosis and liver cancer. HBV e-antigen (HBeAg), a clinical marker for disease severity, is a nonparticulate variant of the protein (core antigen, HBcAg) that forms the building-blocks of capsids. HBeAg is not required for virion production, but is implicated in establishing immune tolerance and chronic infection. Here, we report the crystal structure of HBeAg, which clarifies how the short N-terminal propeptide of HBeAg induces a radically altered mode of dimerization relative to HBcAg ( approximately 140 degrees rotation), locked into place through formation of intramolecular disulfide bridges. This structural switch precludes capsid assembly and engenders a distinct antigenic repertoire, explaining why the two antigens are cross-reactive at the T cell level (through sequence identity) but not at the B cell level (through conformation). The structure offers insight into how HBeAg may establish immune tolerance for HBcAg while evading its robust immunogenicity.
-===Crystal Structure of Hepatitis B Virus e-antigen===
+Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.,Dimattia MA, Watts NR, Stahl SJ, Grimes JM, Steven AC, Stuart DI, Wingfield PT Structure. 2013 Jan 8;21(1):133-42. doi: 10.1016/j.str.2012.10.017. Epub 2012 Dec, 6. PMID:23219881<ref>PMID:23219881</ref>
-{{ABSTRACT_PUBMED_23219881}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 3v6z" style="background-color:#fffaf0;"></div>
-[[3v6z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_b_virus Hepatitis b virus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6Z OCA].
+== References ==
-[[Category: Hepatitis b virus]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Hepatitis B virus]]
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Dimattia, M A.]]
+[[Category: Dimattia MA]]
-[[Category: Grimes, J M.]]
+[[Category: Grimes JM]]
-[[Category: Stahl, S J.]]
+[[Category: Stahl SJ]]
-[[Category: Steven, A C.]]
+[[Category: Steven AC]]
-[[Category: Stuart, D I.]]
+[[Category: Stuart DI]]
-[[Category: Watts, N R.]]
+[[Category: Watts NR]]
-[[Category: Wingfield, P T.]]
+[[Category: Wingfield PT]]
-[[Category: Dimer inversion]]
-[[Category: Four-helix bundle]]
-[[Category: Immune system]]