3bgw: Difference between revisions

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-{{Seed}}
-[[Image:3bgw.png|left|200px]]
-<!--
+==The Structure Of A DnaB-Like Replicative Helicase And Its Interactions With Primase==
-The line below this paragraph, containing "STRUCTURE_3bgw", creates the "Structure Box" on the page.
+<StructureSection load='3bgw' size='340' side='right'caption='[[3bgw]], [[Resolution|resolution]] 3.91&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3bgw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_phage_SPP1 Bacillus phage SPP1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BGW FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.91&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgw OCA], [https://pdbe.org/3bgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bgw RCSB], [https://www.ebi.ac.uk/pdbsum/3bgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bgw ProSAT]</span></td></tr>
-{{STRUCTURE_3bgw|  PDB=3bgw  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q38152_BPSPP Q38152_BPSPP]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bgw_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bgw ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Helicases are essential enzymes for DNA replication, a fundamental process in all living organisms. The DnaB family are hexameric replicative helicases that unwind duplex DNA and coordinate with RNA primase and other proteins at the replication fork in prokaryotes. Here, we report the full-length crystal structure of G40P, a DnaB family helicase. The hexamer complex reveals an unusual architectural feature and a new type of assembly mechanism. The hexamer has two tiers: a three-fold symmetric N-terminal tier and a six-fold symmetric C-terminal tier. Monomers with two different conformations, termed cis and trans, come together to provide a topological solution for the dual symmetry within a hexamer. Structure-guided mutational studies indicate an important role for the N-terminal tier in binding primase and regulating primase-mediated stimulation of helicase activity. This study provides insights into the structural and functional interplay between G40P helicase and DnaG primase.
-===The Structure Of A DnaB-Like Replicative Helicase And Its Interactions With Primase===
+The structure of a DnaB-family replicative helicase and its interactions with primase.,Wang G, Klein MG, Tokonzaba E, Zhang Y, Holden LG, Chen XS Nat Struct Mol Biol. 2008 Jan;15(1):94-100. Epub 2007 Dec 23. PMID:18157148<ref>PMID:18157148</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3bgw" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_18157148}}, adds the Publication Abstract to the page
+*[[Helicase 3D structures|Helicase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 18157148 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_18157148}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Bacillus phage SPP1]]
-BGW is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_phage_spp1 Bacillus phage spp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGW OCA].
+[[Category: Large Structures]]
+[[Category: Chen XS]]
-==Reference==
+[[Category: Holden LG]]
-<ref group="xtra">PMID:18157148</ref><references group="xtra"/>
+[[Category: Klein MG]]
-[[Category: Bacillus phage spp1]]
+[[Category: Tokonzaba E]]
-[[Category: Chen, X S.]]
+[[Category: Wang G]]
-[[Category: Holden, L G.]]
+[[Category: Zhang Y]]
-[[Category: Klein, M G.]]
-[[Category: Tokonzaba, E.]]
-[[Category: Wang, G.]]
-[[Category: Zhang, Y.]]
-[[Category: Atpase]]
-[[Category: Replication]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:34:48 2009''