2rs9: Difference between revisions

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'''Unreleased structure'''


The entry 2rs9 is ON HOLD
==Solution structure of the bromodomain of human BRPF1 in complex with histone H4K5ac peptide==
<StructureSection load='2rs9' size='340' side='right'caption='[[2rs9]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2rs9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RS9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rs9 OCA], [https://pdbe.org/2rs9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rs9 RCSB], [https://www.ebi.ac.uk/pdbsum/2rs9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rs9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>


Authors: Qin, X., Nagashima, T., Umehara, T., Hayashi, F., Yokoyama, S.
==See Also==
 
*[[Peregrin|Peregrin]]
Description: Solution structure of the bromodomain of human BRPF1 in complex with histone H4K5ac peptide
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hayashi F]]
[[Category: Nagashima T]]
[[Category: Qin X]]
[[Category: Umehara T]]
[[Category: Yokoyama S]]

Latest revision as of 10:47, 9 October 2024

Solution structure of the bromodomain of human BRPF1 in complex with histone H4K5ac peptideSolution structure of the bromodomain of human BRPF1 in complex with histone H4K5ac peptide

Structural highlights

2rs9 is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 20 models
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BRPF1_HUMAN Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.[1] [2]

See Also

References

  1. ↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007
  2. ↑ Ullah M, Pelletier N, Xiao L, Zhao SP, Wang K, Degerny C, Tahmasebi S, Cayrou C, Doyon Y, Goh SL, Champagne N, Cote J, Yang XJ. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol Cell Biol. 2008 Nov;28(22):6828-43. doi: 10.1128/MCB.01297-08. Epub 2008 Sep , 15. PMID:18794358 doi:10.1128/MCB.01297-08
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