2pyc: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2pyc.jpg|left|200px]]
- {{Structure
+==Crystal structure of a monomeric phospholipase A2 from Russell's viper at 1.5A resolution==
-|PDB= 2pyc |SIZE=350|CAPTION= <scene name='initialview01'>2pyc</scene>, resolution 1.50&Aring;
+<StructureSection load='2pyc' size='340' side='right'caption='[[2pyc]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>
+<table><tr><td colspan='2'>[[2pyc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_pulchella Daboia russelii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PYC FirstGlance]. <br>
-|ACTIVITY= [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyc OCA], [https://pdbe.org/2pyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pyc RCSB], [https://www.ebi.ac.uk/pdbsum/2pyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pyc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/py/2pyc_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pyc ConSurf].
+<div style="clear:both"></div>
-'''Crystal structure of a monomeric phospholipase A2 from Russell's viper at 1.5A resolution'''
+==See Also==
+*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-PYC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_pulchella Daboia russellii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYC OCA].
+__TOC__
-[[Category: Daboia russellii pulchella]]
+</StructureSection>
-[[Category: Phospholipase A(2)]]
+[[Category: Daboia russelii pulchella]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Betzel, C.]]
+[[Category: Betzel C]]
-[[Category: Kaur, P.]]
+[[Category: Kaur P]]
-[[Category: Kumar, S.]]
+[[Category: Kumar S]]
-[[Category: Sharma, S.]]
+[[Category: Sharma S]]
-[[Category: Singh, N.]]
+[[Category: Singh N]]
-[[Category: Singh, T P.]]
+[[Category: Singh TP]]
-[[Category: ACT]]
-[[Category: CCN]]
-[[Category: SO4]]
-[[Category: active site]]
-[[Category: toxin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:19:31 2008''