2pvk: Difference between revisions

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-{{Seed}}
-[[Image:2pvk.png|left|200px]]
-<!--
+==Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2==
-The line below this paragraph, containing "STRUCTURE_2pvk", creates the "Structure Box" on the page.
+<StructureSection load='2pvk' size='340' side='right'caption='[[2pvk]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2pvk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PVK FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=P45:2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE'>P45</scene></td></tr>
-{{STRUCTURE_2pvk|  PDB=2pvk  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pvk OCA], [https://pdbe.org/2pvk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pvk RCSB], [https://www.ebi.ac.uk/pdbsum/2pvk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pvk ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CSK2A_MAIZE CSK2A_MAIZE] Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pv/2pvk_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pvk ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The structure-based design, synthesis, and anticancer activity of novel inhibitors of protein kinase CK2 are described. Using pyrazolo[1,5-a][1,3,5]triazine as the core scaffold, a structure-guided series of modifications provided pM inhibitors with microM-level cytotoxic activity in cell-based assays with prostate and colon cancer cell lines.
-===Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2===
+Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2.,Nie Z, Perretta C, Erickson P, Margosiak S, Almassy R, Lu J, Averill A, Yager KM, Chu S Bioorg Med Chem Lett. 2007 Aug 1;17(15):4191-5. Epub 2007 May 18. PMID:17540560<ref>PMID:17540560</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2pvk" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_17540560}}, adds the Publication Abstract to the page
+*[[Casein kinase 3D structures|Casein kinase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 17540560 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_17540560}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-PVK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PVK OCA].
-==Reference==
-Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2., Nie Z, Perretta C, Erickson P, Margosiak S, Almassy R, Lu J, Averill A, Yager KM, Chu S, Bioorg Med Chem Lett. 2007 Aug 1;17(15):4191-5. Epub 2007 May 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17540560 17540560]
-[[Category: Non-specific serine/threonine protein kinase]]
-[[Category: Single protein]]
 [[Category: Zea mays]]
-[[Category: Almassy, R.]]
+[[Category: Almassy R]]
-[[Category: Averill, A.]]
+[[Category: Averill A]]
-[[Category: Chu, S.]]
+[[Category: Chu S]]
-[[Category: Erickson, P.]]
+[[Category: Erickson P]]
-[[Category: Lu, J.]]
+[[Category: Lu J]]
-[[Category: Margosiak, S.]]
+[[Category: Margosiak S]]
-[[Category: Nie, Z.]]
+[[Category: Nie Z]]
-[[Category: Perretta, C.]]
+[[Category: Perretta C]]
-[[Category: Yager, K M.]]
+[[Category: Yager KM]]
-[[Category: Casein kinase ii]]
-[[Category: Enzyme-inhibitor complex]]
-[[Category: Protein kinase ck2]]
-[[Category: Structure-based drug design]]
-[[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:42:14 2008''