2per: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{STRUCTURE_2per|  PDB=2per  |  SCENE=  }}
===Crystal Structure of Human Chloride Intracellular Channel protein 2===


==Disease==
==Crystal Structure of Human Chloride Intracellular Channel protein 2==
[[http://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN]] Note=Defects in CLIC2 are a cause of a mental retardation with cardiopathy and seizures. Cardiac features include atrial fibrillation, cardiomegaly, and congestive heart failure.  
<StructureSection load='2per' size='340' side='right'caption='[[2per]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[2per]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PER FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN]] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.<ref>PMID:15147738</ref><ref>PMID:15916532</ref><ref>PMID:17945253</ref>  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MNB:5-MERCAPTO-2-NITRO-BENZOIC+ACID'>MNB</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2per FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2per OCA], [https://pdbe.org/2per PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2per RCSB], [https://www.ebi.ac.uk/pdbsum/2per PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2per ProSAT]</span></td></tr>
[[2per]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PER OCA].  
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN] Note=Defects in CLIC2 are a cause of a mental retardation with cardiopathy and seizures. Cardiac features include atrial fibrillation, cardiomegaly, and congestive heart failure.
== Function ==
[https://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.<ref>PMID:15147738</ref> <ref>PMID:15916532</ref> <ref>PMID:17945253</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/2per_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2per ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Ion channels|Ion channels]]
*[[Ion channels 3D structures|Ion channels 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:018186468</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Liang, Y H.]]
[[Category: Large Structures]]
[[Category: Mi, W.]]
[[Category: Liang YH]]
[[Category: Su, X D.]]
[[Category: Mi W]]
[[Category: Clic2]]
[[Category: Su XD]]
[[Category: Disulfide bond]]
[[Category: Electron transport]]
[[Category: Gst fold]]

Latest revision as of 10:45, 9 October 2024

Crystal Structure of Human Chloride Intracellular Channel protein 2Crystal Structure of Human Chloride Intracellular Channel protein 2

Structural highlights

2per is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

CLIC2_HUMAN Note=Defects in CLIC2 are a cause of a mental retardation with cardiopathy and seizures. Cardiac features include atrial fibrillation, cardiomegaly, and congestive heart failure.

Function

CLIC2_HUMAN Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Board PG, Coggan M, Watson S, Gage PW, Dulhunty AF. CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels. Int J Biochem Cell Biol. 2004 Aug;36(8):1599-612. PMID:15147738 doi:10.1016/j.biocel.2004.01.026
  2. ↑ Dulhunty AF, Pouliquin P, Coggan M, Gage PW, Board PG. A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP. Biochem J. 2005 Aug 15;390(Pt 1):333-43. PMID:15916532 doi:BJ20042113
  3. ↑ Cromer BA, Gorman MA, Hansen G, Adams JJ, Coggan M, Littler DR, Brown LJ, Mazzanti M, Breit SN, Curmi PM, Dulhunty AF, Board PG, Parker MW. Structure of the Janus protein human CLIC2. J Mol Biol. 2007 Nov 30;374(3):719-31. Epub 2007 Sep 20. PMID:17945253 doi:http://dx.doi.org/10.1016/j.jmb.2007.09.041

2per, resolution 2.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2per&oldid=4185660"