2p52: Difference between revisions

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-{{Seed}}
-[[Image:2p52.png|left|200px]]
-<!--
+==mouse p53 DNA-binding domain in zinc-free oxidized state==
-The line below this paragraph, containing "STRUCTURE_2p52", creates the "Structure Box" on the page.
+<StructureSection load='2p52' size='340' side='right'caption='[[2p52]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2p52]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P52 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p52 OCA], [https://pdbe.org/2p52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p52 RCSB], [https://www.ebi.ac.uk/pdbsum/2p52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p52 ProSAT]</span></td></tr>
-{{STRUCTURE_2p52|  PDB=2p52  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/P53_MOUSE P53_MOUSE] Note=p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer.
+== Function ==
+[https://www.uniprot.org/uniprot/P53_MOUSE P53_MOUSE] Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; te function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression (By similarity). Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis, but seems to have to effect on cell-cycle regulation.<ref>PMID:19556538</ref> <ref>PMID:20673990</ref> <ref>PMID:22726440</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p5/2p52_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p52 ConSurf].
+<div style="clear:both"></div>
-===mouse p53 DNA-binding domain in zinc-free oxidized state===
+==See Also==
+*[[P53 3D structures|P53 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-P52 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P52 OCA].
+__TOC__
+</StructureSection>
-==Reference==
+[[Category: Large Structures]]
-Crystal structure of the mouse p53 core domain in zinc-free state., Kwon E, Kim DY, Suh SW, Kim KK, Proteins. 2008 Jan 1;70(1):280-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17876829 17876829]
 [[Category: Mus musculus]]
-[[Category: Single protein]]
+[[Category: Kim DY]]
-[[Category: Kim, D Y.]]
+[[Category: Kim KK]]
-[[Category: Kim, K K.]]
+[[Category: Kwon E]]
-[[Category: Kwon, E.]]
+[[Category: Suh SW]]
-[[Category: Suh, S W.]]
-[[Category: Disulfide bond]]
-[[Category: Dna binding protein]]
-[[Category: Oxidation immunoglobulin fold]]
-[[Category: Zinc finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:58:04 2008''