2mld: Difference between revisions

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==Solution structure of BmKTX-D19K/K6D==
==Solution structure of BmKTX-D19K/K6D==
<StructureSection load='2mld' size='340' side='right'caption='[[2mld]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2mld' size='340' side='right'caption='[[2mld]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mld]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buthus_martensi Buthus martensi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MLD FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mld]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MLD FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mld OCA], [https://pdbe.org/2mld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mld RCSB], [https://www.ebi.ac.uk/pdbsum/2mld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mld ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mld OCA], [https://pdbe.org/2mld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mld RCSB], [https://www.ebi.ac.uk/pdbsum/2mld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mld ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/KAX36_MESMA KAX36_MESMA]] Blocks voltage-gated potassium channels. At 2 uM, blocks rat Kv1.1/KCNA1 and Kv1.3/KCNA3, has a strong effect on rat Kv1.2/KCNA2 and Kv1.6/KCNA6 as well as a moderate effect on Shaker IR.<ref>PMID:9354615</ref> <ref>PMID:20713119</ref>
[https://www.uniprot.org/uniprot/KAX36_MESMA KAX36_MESMA] Blocks voltage-gated potassium channels. At 2 uM, blocks rat Kv1.1/KCNA1 and Kv1.3/KCNA3, has a strong effect on rat Kv1.2/KCNA2 and Kv1.6/KCNA6 as well as a moderate effect on Shaker IR.<ref>PMID:9354615</ref> <ref>PMID:20713119</ref>  


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buthus martensi]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chen, Z]]
[[Category: Mesobuthus martensii]]
[[Category: Hong, J]]
[[Category: Chen Z]]
[[Category: Lin, D]]
[[Category: Hong J]]
[[Category: Wu, Y]]
[[Category: Lin D]]
[[Category: Toxin]]
[[Category: Wu Y]]

Latest revision as of 10:42, 9 October 2024

Solution structure of BmKTX-D19K/K6DSolution structure of BmKTX-D19K/K6D

Structural highlights

2mld is a 1 chain structure with sequence from Mesobuthus martensii. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 20 models
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KAX36_MESMA Blocks voltage-gated potassium channels. At 2 uM, blocks rat Kv1.1/KCNA1 and Kv1.3/KCNA3, has a strong effect on rat Kv1.2/KCNA2 and Kv1.6/KCNA6 as well as a moderate effect on Shaker IR.[1] [2]

See Also

References

  1. ↑ Romi-Lebrun R, Lebrun B, Martin-Eauclaire MF, Ishiguro M, Escoubas P, Wu FQ, Hisada M, Pongs O, Nakajima T. Purification, characterization, and synthesis of three novel toxins from the Chinese scorpion Buthus martensi, which act on K+ channels. Biochemistry. 1997 Nov 4;36(44):13473-82. PMID:9354615 doi:http://dx.doi.org/10.1021/bi971044w
  2. ↑ Gao B, Peigneur S, Tytgat J, Zhu S. A potent potassium channel blocker from Mesobuthus eupeus scorpion venom. Biochimie. 2010 Dec;92(12):1847-53. doi: 10.1016/j.biochi.2010.08.003. Epub 2010 , Aug 14. PMID:20713119 doi:http://dx.doi.org/10.1016/j.biochi.2010.08.003
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