2hu0: Difference between revisions
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<StructureSection load='2hu0' size='340' side='right'caption='[[2hu0]], [[Resolution|resolution]] 2.95Å' scene=''> | <StructureSection load='2hu0' size='340' side='right'caption='[[2hu0]], [[Resolution|resolution]] 2.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2hu0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2hu0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HU0 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hu0 OCA], [https://pdbe.org/2hu0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hu0 RCSB], [https://www.ebi.ac.uk/pdbsum/2hu0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hu0 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hu0 OCA], [https://pdbe.org/2hu0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hu0 RCSB], [https://www.ebi.ac.uk/pdbsum/2hu0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hu0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/NRAM_I04A1 NRAM_I04A1] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.[HAMAP-Rule:MF_04071] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Influenza | [[Category: Influenza A virus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Blackburn | [[Category: Blackburn GM]] | ||
[[Category: Collins | [[Category: Collins PJ]] | ||
[[Category: Gamblin | [[Category: Gamblin SJ]] | ||
[[Category: Haire | [[Category: Haire LF]] | ||
[[Category: Hay | [[Category: Hay AJ]] | ||
[[Category: Lin | [[Category: Lin YP]] | ||
[[Category: Russell | [[Category: Russell RJ]] | ||
[[Category: Skehel | [[Category: Skehel JJ]] | ||
[[Category: Stevens | [[Category: Stevens DJ]] | ||