2g3a: Difference between revisions

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[[Image:2g3a.gif|left|200px]]


{{Structure
==Crystal structure of putative acetyltransferase from Agrobacterium tumefaciens==
|PDB= 2g3a |SIZE=350|CAPTION= <scene name='initialview01'>2g3a</scene>, resolution 1.9&Aring;
<StructureSection load='2g3a' size='340' side='right'caption='[[2g3a]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
<table><tr><td colspan='2'>[[2g3a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_fabrum_str._C58 Agrobacterium fabrum str. C58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G3A FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00583 Acetyltransf_1]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3a OCA], [https://pdbe.org/2g3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g3a RCSB], [https://www.ebi.ac.uk/pdbsum/2g3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g3a ProSAT], [https://www.topsan.org/Proteins/MCSG/2g3a TOPSAN]</span></td></tr>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3a OCA], [http://www.ebi.ac.uk/pdbsum/2g3a PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2g3a RCSB]</span>
</table>
}}
== Function ==
 
[https://www.uniprot.org/uniprot/ATSE_AGRFC ATSE_AGRFC] Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It prefers glucosamine 6-phosphate or dopamine. It can also use the thialysine, N(8)-acetylspermidine, chloramphenicol, puromycin, polymyxin B, and 4-aminobutyrate ethyl ester.<ref>PMID:23184347</ref>
'''Crystal structure of putative acetyltransferase from Agrobacterium tumefaciens'''
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
==About this Structure==
  <jmolCheckbox>
2G3A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3A OCA].  
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g3/2g3a_consurf.spt"</scriptWhenChecked>
[[Category: Agrobacterium tumefaciens]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: Single protein]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Chruszcz, M.]]
  </jmolCheckbox>
[[Category: Cymborowski, M.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g3a ConSurf].
[[Category: Edwards, A.]]
<div style="clear:both"></div>
[[Category: Gu, J.]]
== References ==
[[Category: MCSG, Midwest Center for Structural Genomics.]]
<references/>
[[Category: Mcsg]]
__TOC__
[[Category: Minor, W.]]
</StructureSection>
[[Category: Savchenko, A.]]
[[Category: Agrobacterium fabrum str. C58]]
[[Category: Xu, X.]]
[[Category: Large Structures]]
[[Category: Zheng, H.]]
[[Category: Chruszcz M]]
[[Category: acetylftransferase]]
[[Category: Cymborowski M]]
[[Category: mcsg]]
[[Category: Edwards A]]
[[Category: midwest center for structural genomic]]
[[Category: Gu J]]
[[Category: protein structure initiative]]
[[Category: Joachimiak A]]
[[Category: psi]]
[[Category: Minor W]]
[[Category: structural genomic]]
[[Category: Savchenko A]]
 
[[Category: Xu X]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:26:02 2008''
[[Category: Zheng H]]

Latest revision as of 10:37, 9 October 2024

Crystal structure of putative acetyltransferase from Agrobacterium tumefaciensCrystal structure of putative acetyltransferase from Agrobacterium tumefaciens

Structural highlights

2g3a is a 1 chain structure with sequence from Agrobacterium fabrum str. C58. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

ATSE_AGRFC Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It prefers glucosamine 6-phosphate or dopamine. It can also use the thialysine, N(8)-acetylspermidine, chloramphenicol, puromycin, polymyxin B, and 4-aminobutyrate ethyl ester.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Kuhn ML, Majorek KA, Minor W, Anderson WF. Broad-substrate screen as a tool to identify substrates for bacterial Gcn5-related N-acetyltransferases with unknown substrate specificity. Protein Sci. 2013 Feb;22(2):222-30. doi: 10.1002/pro.2199. Epub 2012 Dec 17. PMID:23184347 doi:http://dx.doi.org/10.1002/pro.2199

2g3a, resolution 1.90Å

Drag the structure with the mouse to rotate

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