1xv8: Difference between revisions

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-[[Image:1xv8.gif|left|200px]]
- {{Structure
+==Crystal Structure of Human Salivary Alpha-Amylase Dimer==
-|PDB= 1xv8 |SIZE=350|CAPTION= <scene name='initialview01'>1xv8</scene>, resolution 3.0&Aring;
+<StructureSection load='1xv8' size='340' side='right'caption='[[1xv8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>
+<table><tr><td colspan='2'>[[1xv8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XV8 FirstGlance]. <br>
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-amylase Alpha-amylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.1 3.2.1.1] </span>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv8 OCA], [https://pdbe.org/1xv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xv8 RCSB], [https://www.ebi.ac.uk/pdbsum/1xv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xv8 ProSAT]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv8 OCA], [http://www.ebi.ac.uk/pdbsum/1xv8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xv8 RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/AMY1A_HUMAN AMY1A_HUMAN] Calcium-binding enzyme that initiates starch digestion in the oral cavity (PubMed:12527308). Catalyzes the hydrolysis of internal (1->4)-alpha-D-glucosidic bonds, yielding a mixture of maltose, isomaltose, small amounts of glucose as well as small linear and branched oligosaccharides called dextrins (PubMed:12527308).<ref>PMID:12527308</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xv/1xv8_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xv8 ConSurf].
+<div style="clear:both"></div>
-'''Crystal Structure of Human Salivary Alpha-Amylase Dimer'''
+==See Also==
+*[[Amylase 3D structures|Amylase 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-XV8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV8 OCA].
+__TOC__
-[[Category: Alpha-amylase]]
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Fisher, S Z.]]
+[[Category: Fisher SZ]]
-[[Category: Govindasamy, L.]]
+[[Category: Govindasamy L]]
-[[Category: McKenna, R.]]
+[[Category: McKenna R]]
-[[Category: Rajaniemi, H.]]
+[[Category: Rajaniemi H]]
-[[Category: Silverman, D N.]]
+[[Category: Silverman DN]]
-[[Category: Tu, C K.]]
+[[Category: Tu CK]]
-[[Category: dimer]]
-[[Category: hsa]]
-[[Category: human salivary alpha-amylase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:55:05 2008''