1xv8: Difference between revisions

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[[Image:1xv8.png|left|200px]]


{{STRUCTURE_1xv8|  PDB=1xv8  |  SCENE=  }}
==Crystal Structure of Human Salivary Alpha-Amylase Dimer==
 
<StructureSection load='1xv8' size='340' side='right'caption='[[1xv8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
===Crystal Structure of Human Salivary Alpha-Amylase Dimer===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1xv8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XV8 FirstGlance]. <br>
{{ABSTRACT_PUBMED_016511271}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xv8 OCA], [https://pdbe.org/1xv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xv8 RCSB], [https://www.ebi.ac.uk/pdbsum/1xv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xv8 ProSAT]</span></td></tr>
[[1xv8]] is a 2 chain structure of [[Alpha-Amylase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XV8 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/AMY1A_HUMAN AMY1A_HUMAN] Calcium-binding enzyme that initiates starch digestion in the oral cavity (PubMed:12527308). Catalyzes the hydrolysis of internal (1->4)-alpha-D-glucosidic bonds, yielding a mixture of maltose, isomaltose, small amounts of glucose as well as small linear and branched oligosaccharides called dextrins (PubMed:12527308).<ref>PMID:12527308</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xv/1xv8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xv8 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Alpha-Amylase|Alpha-Amylase]]
*[[Amylase 3D structures|Amylase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:016511271</ref><references group="xtra"/>
__TOC__
[[Category: Alpha-amylase]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Fisher, S Z.]]
[[Category: Large Structures]]
[[Category: Govindasamy, L.]]
[[Category: Fisher SZ]]
[[Category: McKenna, R.]]
[[Category: Govindasamy L]]
[[Category: Rajaniemi, H.]]
[[Category: McKenna R]]
[[Category: Silverman, D N.]]
[[Category: Rajaniemi H]]
[[Category: Tu, C K.]]
[[Category: Silverman DN]]
[[Category: Dimer]]
[[Category: Tu CK]]
[[Category: Hsa]]
[[Category: Human salivary alpha-amylase]]
[[Category: Hydrolase]]

Latest revision as of 10:31, 9 October 2024

Crystal Structure of Human Salivary Alpha-Amylase DimerCrystal Structure of Human Salivary Alpha-Amylase Dimer

Structural highlights

1xv8 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AMY1A_HUMAN Calcium-binding enzyme that initiates starch digestion in the oral cavity (PubMed:12527308). Catalyzes the hydrolysis of internal (1->4)-alpha-D-glucosidic bonds, yielding a mixture of maltose, isomaltose, small amounts of glucose as well as small linear and branched oligosaccharides called dextrins (PubMed:12527308).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Ramasubbu N, Ragunath C, Mishra PJ. Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase. J Mol Biol. 2003 Jan 31;325(5):1061-76. PMID:12527308

1xv8, resolution 3.00Å

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OCA
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