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==Crystal Structure of IPMDH from Sulfolobus tokodaii== | ==Crystal Structure of IPMDH from Sulfolobus tokodaii== | ||
<StructureSection load='1wpw' size='340' side='right' caption='[[1wpw]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='1wpw' size='340' side='right'caption='[[1wpw]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1wpw]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1wpw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii Sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WPW FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpw OCA], [https://pdbe.org/1wpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wpw RCSB], [https://www.ebi.ac.uk/pdbsum/1wpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wpw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/LEU3_SULTO LEU3_SULTO] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 15: | Line 15: | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wp/1wpw_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wp/1wpw_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| Line 25: | Line 25: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Sulfurisphaera tokodaii]] | ||
[[Category: Hirose | [[Category: Hirose R]] | ||
[[Category: Moriyama | [[Category: Moriyama H]] | ||
[[Category: Oshima | [[Category: Oshima T]] | ||
[[Category: Sakurai | [[Category: Sakurai M]] | ||
[[Category: Sato | [[Category: Sato T]] | ||
[[Category: Suzuki | [[Category: Suzuki T]] | ||
[[Category: Tanaka | [[Category: Tanaka N]] | ||
[[Category: Yamagishi | [[Category: Yamagishi A]] | ||
Latest revision as of 10:29, 9 October 2024
Crystal Structure of IPMDH from Sulfolobus tokodaiiCrystal Structure of IPMDH from Sulfolobus tokodaii
Structural highlights
FunctionLEU3_SULTO Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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