1td5: Difference between revisions

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-{{Seed}}
-[[Image:1td5.png|left|200px]]
-<!--
+==Crystal Structure of the Ligand Binding Domain of E. coli IclR.==
-The line below this paragraph, containing "STRUCTURE_1td5", creates the "Structure Box" on the page.
+<StructureSection load='1td5' size='340' side='right'caption='[[1td5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1td5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TD5 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-{{STRUCTURE_1td5|  PDB=1td5  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1td5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1td5 OCA], [https://pdbe.org/1td5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1td5 RCSB], [https://www.ebi.ac.uk/pdbsum/1td5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1td5 ProSAT], [https://www.topsan.org/Proteins/MCSG/1td5 TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ICLR_ECOLI ICLR_ECOLI] Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyruvate enhances promoter binding by stabilizing the tetrameric form.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/td/1td5_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1td5 ConSurf].
+<div style="clear:both"></div>
-===Crystal Structure of the Ligand Binding Domain of E. coli IclR.===
+==See Also==
+*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-TD5 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TD5 OCA].
 [[Category: Escherichia coli]]
-[[Category: Arrowsmith, C.]]
+[[Category: Large Structures]]
-[[Category: Bochkarev, A.]]
+[[Category: Arrowsmith C]]
-[[Category: Edwards, A.]]
+[[Category: Bochkarev A]]
-[[Category: Evdokimova, L.]]
+[[Category: Edwards A]]
-[[Category: Joachimiak, A.]]
+[[Category: Evdokimova L]]
-[[Category: MCSG, Midwest Center for Structural Genomics.]]
+[[Category: Joachimiak A]]
-[[Category: Savchenko, A.]]
+[[Category: Savchenko A]]
-[[Category: Walker, J R.]]
+[[Category: Walker JR]]
-[[Category: Zhang, R G.]]
+[[Category: Zhang R-G]]
-[[Category: Alpha/beta domain,ligand binding domain]]
-[[Category: Mcsg]]
-[[Category: Midwest center for structural genomic]]
-[[Category: Protein structure initiative]]
-[[Category: Psi]]
-[[Category: Transcription regulator]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 12:12:29 2008''