1hzx: Difference between revisions

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[[Image:1hzx.png|left|200px]]


{{STRUCTURE_1hzx|  PDB=1hzx  |  SCENE=  }}
==CRYSTAL STRUCTURE OF BOVINE RHODOPSIN==
 
<StructureSection load='1hzx' size='340' side='right'caption='[[1hzx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
===CRYSTAL STRUCTURE OF BOVINE RHODOPSIN===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1hzx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HZX FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=HTO:HEPTANE-1,2,3-TRIOL'>HTO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[1hzx]] is a 2 chain structure of [[Rhodopsin]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZX OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzx OCA], [https://pdbe.org/1hzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hzx RCSB], [https://www.ebi.ac.uk/pdbsum/1hzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hzx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hz/1hzx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hzx ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Rhodopsin|Rhodopsin]]
*[[Rhodopsin 3D structures|Rhodopsin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:011425302</ref><ref group="xtra">PMID:015170322</ref><ref group="xtra">PMID:015595835</ref><ref group="xtra">PMID:018563085</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Behnke, C A.]]
[[Category: Large Structures]]
[[Category: Okada, T.]]
[[Category: Behnke CA]]
[[Category: Palczewski, K.]]
[[Category: Okada T]]
[[Category: Stenkamp, R E.]]
[[Category: Palczewski K]]
[[Category: Teller, D C.]]
[[Category: Stenkamp RE]]
[[Category: G-protein-coupled receptor]]
[[Category: Teller DC]]
[[Category: Membrane protein photoreceptor cell]]
[[Category: Phototransduction]]
[[Category: Signaling protein]]

Latest revision as of 10:17, 9 October 2024

CRYSTAL STRUCTURE OF BOVINE RHODOPSINCRYSTAL STRUCTURE OF BOVINE RHODOPSIN

Structural highlights

1hzx is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Ligands:, , , , , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OPSD_BOVIN Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Nakamichi H, Okada T. Local peptide movement in the photoreaction intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12729-34. Epub 2006 Aug 14. PMID:16908857
  2. ↑ Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607

1hzx, resolution 2.80Å

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