1h3t: Difference between revisions

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 ==Crystal structure of the human igg1 fc-fragment,glycoform (mn2f)2==
-<StructureSection load='1h3t' size='340' side='right' caption='[[1h3t]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+<StructureSection load='1h3t' size='340' side='right'caption='[[1h3t]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1h3t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H3T FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1h3t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H3T FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h3u|1h3u]], [[1h3v|1h3v]], [[1h3w|1h3w]], [[1h3x|1h3x]], [[1h3y|1h3y]], [[1aj7|1aj7]], [[1d5b|1d5b]], [[1d5i|1d5i]], [[1d6v|1d6v]], [[1dn2|1dn2]], [[1e4k|1e4k]], [[1fc1|1fc1]], [[1fc2|1fc2]], [[1fcc|1fcc]], [[1hzh|1hzh]], [[1i7z|1i7z]], [[1iis|1iis]], [[1iix|1iix]], [[2rcs|2rcs]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h3t OCA], [http://pdbe.org/1h3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h3t RCSB], [http://www.ebi.ac.uk/pdbsum/1h3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h3t ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h3t OCA], [https://pdbe.org/1h3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h3t RCSB], [https://www.ebi.ac.uk/pdbsum/1h3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h3t ProSAT]</span></td></tr>
 </table>
+== Disease ==
+[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
+== Function ==
+[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/1h3t_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/1h3t_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 32: / Line 36: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Huber, R]]
+[[Category: Large Structures]]
-[[Category: Jefferis, R]]
+[[Category: Huber R]]
-[[Category: Krapp, S]]
+[[Category: Jefferis R]]
-[[Category: Mimura, Y]]
+[[Category: Krapp S]]
-[[Category: Sondermann, P]]
+[[Category: Mimura Y]]
-[[Category: Antibody]]
+[[Category: Sondermann P]]
-[[Category: Effector function]]
-[[Category: Fcgr]]
-[[Category: Glycosylation]]
-[[Category: Immune system]]
-[[Category: Immunoglobulin]]