1b3j: Difference between revisions

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-[[Image:1b3j.gif|left|200px]]
-<!--
+==STRUCTURE OF THE MHC CLASS I HOMOLOG MIC-A, A GAMMADELTA T CELL LIGAND==
-The line below this paragraph, containing "STRUCTURE_1b3j", creates the "Structure Box" on the page.
+<StructureSection load='1b3j' size='340' side='right'caption='[[1b3j]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1b3j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B3J FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-{{STRUCTURE_1b3j|  PDB=1b3j  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b3j OCA], [https://pdbe.org/1b3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b3j RCSB], [https://www.ebi.ac.uk/pdbsum/1b3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b3j ProSAT]</span></td></tr>
+</table>
-'''STRUCTURE OF THE MHC CLASS I HOMOLOG MIC-A, A GAMMADELTA T CELL LIGAND'''
+== Disease ==
+[https://www.uniprot.org/uniprot/MICA_HUMAN MICA_HUMAN] Note=Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma.  Genetic variations in MICA may be a cause of susceptibility to psoriasis type 1 (PSORS1) [MIM:[https://omim.org/entry/177900 177900]. Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.  Genetic variation in MICA is a cause of susceptibility to psoriatic arthritis (PSORAS) [MIM:[https://omim.org/entry/607507 607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
+== Function ==
-==Overview==
+[https://www.uniprot.org/uniprot/MICA_HUMAN MICA_HUMAN] Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.<ref>PMID:9497295</ref> <ref>PMID:10426993</ref> <ref>PMID:11491531</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/1b3j_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b3j ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
 The major histocompatibility complex (MHC) class I homolog MIC-A functions as a stress-inducible antigen that is recognized by a subset of gammadelta T cells independent of beta2-microglobulin and bound peptides. Its crystal structure reveals a dramatically altered MHC class I fold, both in detail and overall domain organization. The only remnant of a peptide-binding groove is a small cavity formed as the result of disordering a large section of one of the groove-defining helices. Loss of beta2-microglobulin binding is due to a restructuring of the interaction interfaces. Structural mapping of sequence variation suggests potential receptor binding sites on the underside of the platform on the side opposite of the surface recognized by alphabeta T cell receptors on MHC class I-peptide complexes.
-==About this Structure==
+Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand.,Li P, Willie ST, Bauer S, Morris DL, Spies T, Strong RK Immunity. 1999 May;10(5):577-84. PMID:10367903<ref>PMID:10367903</ref>
-B3J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B3J OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand., Li P, Willie ST, Bauer S, Morris DL, Spies T, Strong RK, Immunity. 1999 May;10(5):577-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10367903 10367903]
+</div>
+<div class="pdbe-citations 1b3j" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Bauer, S.]]
+[[Category: Bauer S]]
-[[Category: Li, P.]]
+[[Category: Li P]]
-[[Category: Morris, D.]]
+[[Category: Morris D]]
-[[Category: Spies, T.]]
+[[Category: Spies T]]
-[[Category: Strong, R.]]
+[[Category: Strong R]]
-[[Category: Willie, S.]]
+[[Category: Willie S]]
-[[Category: Gamma-delta-tcr]]
-[[Category: Glycoprotein]]
-[[Category: Hc i homolog]]
-[[Category: Human mica]]
-[[Category: Immunology]]
-[[Category: Mhc]]
-[[Category: Mica]]
-[[Category: Signa immunoglobulin fold]]
-[[Category: T-cell]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:01:09 2008''