6lb5: Difference between revisions

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'''Unreleased structure'''


The entry 6lb5 is ON HOLD  until Paper Publication
==Crystal structure of dimeric RXR-LBD complexed with full agonist NEt-3IB and TIF2 co-activator==
 
<StructureSection load='6lb5' size='340' side='right'caption='[[6lb5]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors: Imai, D., Numoto, N., Nakano, S., Kakuta, H., Ito, N.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6lb5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LB5 FirstGlance]. <br>
Description: Crystal structure of dimeric RXR-LBD complexed with full agonist NEt-3IB and TIF2 co-activator
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E80:6-[ethyl-[3-(2-methylpropoxy)-4-propan-2-yl-phenyl]amino]pyridine-3-carboxylic+acid'>E80</scene></td></tr>
[[Category: Imai, D]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lb5 OCA], [https://pdbe.org/6lb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lb5 RCSB], [https://www.ebi.ac.uk/pdbsum/6lb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lb5 ProSAT]</span></td></tr>
[[Category: Nakano, S]]
</table>
[[Category: Numoto, N]]
== Disease ==
[[Category: Kakuta, H]]
[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
[[Category: Ito, N]]
== Function ==
[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Imai D]]
[[Category: Ito N]]
[[Category: Kakuta H]]
[[Category: Nakano S]]
[[Category: Numoto N]]

Latest revision as of 07:07, 5 October 2024

Crystal structure of dimeric RXR-LBD complexed with full agonist NEt-3IB and TIF2 co-activatorCrystal structure of dimeric RXR-LBD complexed with full agonist NEt-3IB and TIF2 co-activator

Structural highlights

6lb5 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

NCOA2_HUMAN Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.

Function

NCOA2_HUMAN Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.[1]

References

  1. Voegel JJ, Heine MJ, Tini M, Vivat V, Chambon P, Gronemeyer H. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J. 1998 Jan 15;17(2):507-19. PMID:9430642 doi:10.1093/emboj/17.2.507

6lb5, resolution 2.40Å

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OCA