8uy6: Difference between revisions

Latest revision as of 08:09, 25 September 2024

Aquaporin Z with ALFA tag and bound to nanobodyAquaporin Z with ALFA tag and bound to nanobody

Structural highlights

8uy6 is a 16 chain structure with sequence from Escherichia coli and Vicugna pacos. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 1.9Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AQPZ_ECOLI Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.^[1] ^[2] ^[3]

References

↑ Delamarche C, Thomas D, Rolland JP, Froger A, Gouranton J, Svelto M, Agre P, Calamita G. Visualization of AqpZ-mediated water permeability in Escherichia coli by cryoelectron microscopy. J Bacteriol. 1999 Jul;181(14):4193-7. PMID:10400575
↑ Borgnia MJ, Kozono D, Calamita G, Maloney PC, Agre P. Functional reconstitution and characterization of AqpZ, the E. coli water channel protein. J Mol Biol. 1999 Sep 3;291(5):1169-79. PMID:10518952 doi:http://dx.doi.org/S0022-2836(99)93032-2
↑ Pohl P, Saparov SM, Borgnia MJ, Agre P. Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9624-9. Epub 2001 Aug 7. PMID:11493683 doi:http://dx.doi.org/10.1073/pnas.161299398

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OCA

[1] Delamarche C, Thomas D, Rolland JP, Froger A, Gouranton J, Svelto M, Agre P, Calamita G. Visualization of AqpZ-mediated water permeability in Escherichia coli by cryoelectron microscopy. J Bacteriol. 1999 Jul;181(14):4193-7. PMID:10400575

[2] Borgnia MJ, Kozono D, Calamita G, Maloney PC, Agre P. Functional reconstitution and characterization of AqpZ, the E. coli water channel protein. J Mol Biol. 1999 Sep 3;291(5):1169-79. PMID:10518952 doi:http://dx.doi.org/S0022-2836(99)93032-2

[3] Pohl P, Saparov SM, Borgnia MJ, Agre P. Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9624-9. Epub 2001 Aug 7. PMID:11493683 doi:http://dx.doi.org/10.1073/pnas.161299398

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8uy6 is ON HOLD  until Paper Publication
+==Aquaporin Z with ALFA tag and bound to nanobody==
+<StructureSection load='8uy6' size='340' side='right'caption='[[8uy6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-Authors: Stover, L., Bahramimoghaddam, H., Wang, L., Zhou, M., Laganowsky, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8uy6]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UY6 FirstGlance]. <br>
-Description: Aquaporin Z with ALFA tag and bound to nanobody
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene></td></tr>
-[[Category: Wang, L]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uy6 OCA], [https://pdbe.org/8uy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uy6 RCSB], [https://www.ebi.ac.uk/pdbsum/8uy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uy6 ProSAT]</span></td></tr>
-[[Category: Laganowsky, A]]
+</table>
-[[Category: Zhou, M]]
+== Function ==
-[[Category: Stover, L]]
+[https://www.uniprot.org/uniprot/AQPZ_ECOLI AQPZ_ECOLI] Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.<ref>PMID:10400575</ref> <ref>PMID:10518952</ref> <ref>PMID:11493683</ref>
-[[Category: Bahramimoghaddam, H]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Escherichia coli]]
+[[Category: Large Structures]]
+[[Category: Vicugna pacos]]
+[[Category: Bahramimoghaddam H]]
+[[Category: Laganowsky A]]
+[[Category: Stover L]]
+[[Category: Wang L]]
+[[Category: Zhou M]]

8uy6: Difference between revisions

Latest revision as of 08:09, 25 September 2024

Aquaporin Z with ALFA tag and bound to nanobodyAquaporin Z with ALFA tag and bound to nanobody

Structural highlights

Function

References

Contents

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8uy6: Difference between revisions

Latest revision as of 08:09, 25 September 2024

Aquaporin Z with ALFA tag and bound to nanobodyAquaporin Z with ALFA tag and bound to nanobody

Structural highlights

Function

References

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