8olc: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==SA11 Rotavirus Trypsinized Triple Layered Particle== | |||
<StructureSection load='8olc' size='340' side='right'caption='[[8olc]], [[Resolution|resolution]] 3.48Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8olc]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Rotavirus Rotavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OLC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.48Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8olc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8olc OCA], [https://pdbe.org/8olc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8olc RCSB], [https://www.ebi.ac.uk/pdbsum/8olc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8olc ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: Luque | [https://www.uniprot.org/uniprot/A0A060IEQ1_9REOV A0A060IEQ1_9REOV] Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion. This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.[HAMAP-Rule:MF_04130] Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.[RuleBase:RU363022] | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Rotavirus]] | |||
[[Category: Asensio-Cob D]] | |||
[[Category: Gomez-Blanco J]] | |||
[[Category: Luque D]] | |||
[[Category: Perez-Mata C]] | |||
[[Category: Rodriguez JM]] | |||
[[Category: Vargas J]] | |||
Latest revision as of 08:06, 25 September 2024
SA11 Rotavirus Trypsinized Triple Layered ParticleSA11 Rotavirus Trypsinized Triple Layered Particle
Structural highlights
FunctionA0A060IEQ1_9REOV Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion. This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.[HAMAP-Rule:MF_04130] Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.[RuleBase:RU363022] |
| ||||||||||||||||||