Alpha-synuclein: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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-<StructureSection load='6flt' size='340' side='right' caption='Human alpha-synuclein (PDB [[6flt]])' scene=''>
+<StructureSection load='6h6b' size='340' side='right' caption='Human alpha-synuclein (PDB [[6h6b]])' scene='84/840509/Cv/1'>
 == Function ==
-'''Alpha-Synuclein''' (Syn) is a human neuronal protein which has several roles in synaptic activity. Syn enhances vesicle priming, fusion and dilation of exocytotic pores<ref>PMID:28288128/ref>.  Syn acts as a molecular chaperone in assisting the folding of SNAREs - the synaptic fusion components<ref>PMID:20798282</ref>.  Syn associates with the dopamine transporter and modulates its activity<ref>PMID:26442590</ref>.
+'''Alpha-Synuclein''' (Syn) is a human neuronal protein which has several roles in synaptic activity. Syn enhances vesicle priming, fusion and dilation of exocytotic pores<ref>PMID:28288128</ref>.  Syn acts as a molecular chaperone in assisting the folding of SNAREs - the synaptic fusion components<ref>PMID:20798282</ref>. Syn associates with the dopamine transporter and modulates its activity<ref>PMID:26442590</ref>.
 == Disease ==
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 == Structural highlights ==
-The Syn structure shows 8 β-sheet forming segments interrupted by Gly residues.  Seven PD-associated familial mutations are known.  The 3D structure shows a hydrophobic cleft which can provide an entry point for an incoming Syn molecule elongating the fibril<ref>PMID:29969391</ref>.
+The Syn structure shows <scene name='84/840509/Cv/2'>8 β-sheet</scene> forming segments interrupted by <scene name='84/840509/Cv/4'>Gly residues</scene>. Seven PD-associated familial <scene name='84/840509/Cv/5'>mutations</scene> are known. The 3D structure shows a <scene name='84/840509/Cv/6'>hydrophobic cleft</scene> which can provide an entry point for an incoming Syn molecule elongating the fibril<ref>PMID:29969391</ref>.
-</StructureSection>
 == 3D Structures of alpha-synuclein==
+[[Alpha-synuclein 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[6flt]], [[6h6b]], [[6a6b]], [[6cu7]], [[6cu8]], [[6rt0]], [[6rtb]], [[6sst]], [[6ssx]], [[6xyo]], [[6xyp]], [[6xyq]], [[6osj]], [[6osl]], [[6osm]] – hSyn – human - Cryo EM<br />
-[[2n0a]] – hSyn – NMR<br />
-[[6ufr]], [[6peo]], [[6pes]] – hSyn (mutant) - Cryo EM<br />
-[[2m55]] – hSyn residues 1-19 + calmodulin – NMR<br />
-[[6i42]] – hSyn residues 48-60 + cyclophilin A<br />
-[[5crw]] – hSyn residues 31-41 + protein disulfide isomerase<br />
-[[6ct7]] – hSyn residues 1-10 + antibody<br />
-[[2x6m]] – hSyn residues 132-140 + antibody<br />
-[[3q25]], [[3q26]], [[3q27]], [[3q28]], [[3q29]] – hSyn peptide/MBP<br />
-[[3q26]] – hSyn residues 10-42/MBP<br />
-[[4r0u]], [[4r0w]], [[4rik]], [[4ril]] - hSyn amyloid-forming peptide<br />
-[[4znn]] - hSyn amyloid-forming peptide (mutant)<br />
 == References ==
 <references/>
+</StructureSection>
 [[Category:Topic Page]]