Cadherin: Difference between revisions

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Alexander Berchansky, Michal Harel

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 <StructureSection load='2a4c' size='350' side='right' scene='41/417481/Cv/4' caption='Mouse cadherin-11 EC1 dimer (PDB code [[2a4c]])'>
+__TOC__
+== Function ==
-== Function ==
+[[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins.  They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions.  They are encoded by numerous genes numbered CDH1-CDH23.   Some names of CDH indicate their locations: '''E-CDH''' (epithelial tissue), '''VE-CDH''' (vascular epithelial), '''T-CDH''' bound to membrane, '''N-CDH''' (neurons), '''P-CDH''' (placental), '''K-CDH''' (kidney).  The CDH superfamily contains:<br />
+*'''Protocadhedrins''' (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains.  They are found mainly in the brain at cell-cell contacts.<ref>PMID:11171368</ref> <br />
+*'''Desmogleins''' (Des-CDH) and '''desmocollin''' are CDH found in desmosomes.
-[[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins.  They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions.  They are encoded by numerous genes numbered CDH1-CDH23.   Some names of CDH indicate their locations: '''E-CDH''' (epithelial tissue), '''VE-CDH''' (vascular epithelial), '''T-CDH''' bound to membrane, '''N-CDH''' (neurons), '''P-CDH''' (placental), '''K-CDH''' (kidney).  The CDH superfamily contains:<br /> *'''Protocadhedrins''' (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains.  They are found mainly in the brain at cell-cell contacts.<ref>PMID:11171368</ref> <br />
-*'''Desmogleins''' (Des-CDH) are CDH found in desmosomes.
 == Structural highlights ==