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| <StructureSection load='2a4c' size='450' side='right' scene='41/417481/Cv/2' caption='Mouse cadherin-11 EC1 dimer (PDB code [[2a4c]])'> | | <StructureSection load='2a4c' size='350' side='right' scene='41/417481/Cv/4' caption='Mouse cadherin-11 EC1 dimer (PDB code [[2a4c]])'> |
| | __TOC__ |
| == Function == | | == Function == |
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| [[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: '''E-CDH''' (epithelial tissue), '''VE-CDH''' (vascular epithelial), '''T-CDH''' bound to membrane, '''N-CDH''' (neurons), '''P-CDH''' (placental). The CDH superfamily contains:<br /> *'''Protocadhedrins''' (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains. They are found mainly in the brain at cell-cell contacts.<br /> | | [[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: '''E-CDH''' (epithelial tissue), '''VE-CDH''' (vascular epithelial), '''T-CDH''' bound to membrane, '''N-CDH''' (neurons), '''P-CDH''' (placental), '''K-CDH''' (kidney). The CDH superfamily contains:<br /> |
| *'''Desmogleins''' (Des-CDH) are CDH found in desmosomes. | | *'''Protocadhedrins''' (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains. They are found mainly in the brain at cell-cell contacts.<ref>PMID:11171368</ref> <br /> |
| | *'''Desmogleins''' (Des-CDH) and '''desmocollin''' are CDH found in desmosomes. |
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| == Structural highlights == | | == Structural highlights == |
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| The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed ''strand swap''. The strand swapping is enhanced by 2 Trp residues docking into the hydrophobic pocket of the neighboring CDH molecule. | | The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed ''strand swap''. The strand swapping is enhanced by <scene name='41/417481/Cv/5'>2 Trp residues</scene> docking into the hydrophobic pocket of the neighboring CDH molecule. <ref>PMID:16564015</ref> |
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| </StructureSection> | |
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| == 3D Structures of Cadherin == | | == 3D Structures of Cadherin == |
| | [[Cadherin 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| * CDH1
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| **[[1q1p]] – mCDH1 - mouse<br />
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| **[[3q2v]] – mCDH1 ectodomain<br />
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| **[[3qrb]] – mCDH1+2
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| * CDH5
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| **[[2koh]] – mCDH5+PAR3-PDZ3<br />
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| * CDH6
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| **[[3lnd]] – mCDH6 EC12 (mutant)<br />
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| * CDH8
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| **[[1zxk]] – mCDH8 EC1<br />
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| **[[2a62]] - mCDH8 EC1+EC2+EC3<br />
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| * CDH11
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| **[[2a4c]], [[2a4e]] – mCDH11 EC1<br />
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| * CDH20
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| **[[1zvn]] – cCDH20 EC1 – chicken<br />
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| * CDH23
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| **[[3mvs]], [[2whv]] – mCDH23 N-terminal<br />
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| **[[2kbr]] – hCDH23 peptide+harmonin – NMR - human<br />
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| **[[2kbs]] - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR<br />
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| **[[2wbx]] – mCDH23 EC1<br />
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| **[[2wcp]] - mCDH23 EC2<br />
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| **[[2wd0]] - mCDH23 EC1+EC2 (mutant)<br />
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| **[[4apx]], [[4aq8]], [[4axw]] - mCDH23 EC1+EC2 + Prot-CDH15<br />
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| **[[4aqa]], [[4aqe]] - mCDH23 EC1+EC2 (mutant) + Prot-CDH15
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| * C-CDH “classical”
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| **[[1l3w]] – XlC-CDH ectodomain - ''Xenopus laevis''<br />
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| **[[1q5b]], [[1q5c]], [[1q55]], [[1q5a]] – C-CDH model into desmosome – electron tomography<br />
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| * E-CDH epithelial
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| **[[1edh]] - mE-CDH EC1+EC2+Ca<br />
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| **[[3q2l]], [[3q2n]] - mE-CDH EC1+EC2 (mutant)<br />
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| **[[1suh]] – mE-CDH N-terminal - NMR<br />
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| **[[3l6x]], [[3l6y]], [[1i7x]], [[1i7w]] – mE-CDH+catenin<br />
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| **[[3lne]], [[3lnf]], [[3lng]], [[3lnh]], [[3lni]] – mE-CDH EC12 (mutant)<br />
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| **[[2qvf]] – mE-CDH1 CDH2<br />
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| **[[4qd2]] – mE-CDH + botulinum neurotoxin<br />
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| **[[3ifq]] – hE-CDH EC1+EC2+EC3 <br />
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| **[[2o72]] - hE-CDH EC1+EC2<br />
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| **[[3ff7]], [[3ff8]] - hE-CDH EC1+EC2+EC3+NK cell receptor<br />
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| **[[2omt]], [[2omu]], [[2omx]], [[2omz]], [[2omv]], [[2omw]], [[2omy]] – hE-CDH EC1+internalin (mutant)<br />
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| **[[1o6s]] – E-CDH N-terminal+internalin – ''Listeria monocytogenes''<br />
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| * T-CDH membrane bound
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| **[[3k5r]] – mT-CDH EC1+EC2<br />
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| **[[3k5s]] - cT-CDH EC1+EC2 <br />
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| **[[3k6d]] - XlT-CDH EC1 <br />
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| **[[3k6f]] - mT-CDH EC1<br />
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| **[[3k6i]] - cT-CDH EC1<br />
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| **[[2v37]] – hT-CDH N-terminal - NMR<br />
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| * N-CDH neuronal
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| **[[1nch]], [[1nci]] – mN-CDH<br />
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| **[[1ncg]] – mN-CDH (mutant)<br />
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| **[[2qvi]], [[4nuq]] – mN-CDH EC1-EC2<br />
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| **[[4num]], [[4nup]] – mN-CDH EC1-EC2 (mutant)<br />
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| **[[1ncj]] – mN-CDH two domains<br />
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| **[[3q2w]] – mN-CDH ectodomain<br />
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| **[[1op4]] - mN-CDH prodomain - NMR<br />
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| **[[3ubf]] – DmN-CDH ectodomain – ''Drosophila melanogaster''<br />
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| **[[3ubh]] - DmN-CDH EC1-4<br />
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| **[[3ubg]] - DmN-CDH EC1-3
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| *P-CDH placental
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| **[[4nqq]] – mP-CDH EC1+EC2<br />
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| *VE-CDH vascular epithelial
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| **[[3ppe]] – cVE-CDH EC1+EC2<br />
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| * Protocadherin
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| **[[2yst]] – hProt-CDH7 EC3 – NMR<br />
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| **[[2ee0]] - hProt-CDH9 Ca domain – NMR<br />
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| **[[1wyj]] - mProt-CDH β 14 - NMR<br />
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| **[[1wuz]] - mProt-CDH4 EC1 – NMR
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| * Desmoglein
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| **[[2yqg]] – hDes-CDH EC1<br />
| | == References == |
| }}
| | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |