6lk8: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6lk8 is ON HOLD
+==Structure of Xenopus laevis Cytoplasmic Ring subunit.==
+<StructureSection load='6lk8' size='340' side='right'caption='[[6lk8]], [[Resolution|resolution]] 5.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6lk8]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LK8 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.5&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lk8 OCA], [https://pdbe.org/6lk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lk8 RCSB], [https://www.ebi.ac.uk/pdbsum/6lk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lk8 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q7ZYJ8_XENLA Q7ZYJ8_XENLA]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The nuclear pore complex (NPC) exhibits structural plasticity and has only been characterized at local resolutions of up to 15 A for the cytoplasmic ring (CR). Here we present a single-particle cryo-electron microscopy (cryo-EM) structure of the CR from Xenopus laevis NPC at average resolutions of 5.5-7.9 A, with local resolutions reaching 4.5 A. Improved resolutions allow identification and placement of secondary structural elements in the majority of the CR components. The two Y complexes in each CR subunit interact with each other and associate with those from flanking subunits, forming a circular scaffold. Within each CR subunit, the Nup358-containing region wraps around the stems of both Y complexes, likely stabilizing the scaffold. Nup205 connects the short arms of the two Y complexes and associates with the stem of a neighboring Y complex. The Nup214-containing region uses an extended coiled-coil to link Nup85 of the two Y complexes and protrudes into the axial pore of the NPC. These previously uncharacterized structural features reveal insights into NPC assembly.
-Authors:
+Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis.,Huang G, Zhang Y, Zhu X, Zeng C, Wang Q, Zhou Q, Tao Q, Liu M, Lei J, Yan C, Shi Y Cell Res. 2020 Jun;30(6):520-531. doi: 10.1038/s41422-020-0319-4. Epub 2020 May , 6. PMID:32376910<ref>PMID:32376910</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 6lk8" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Xenopus laevis]]
+[[Category: Huang G]]
+[[Category: Shi Y]]
+[[Category: Yan C]]
+[[Category: Zhang Y]]