3ffl: Difference between revisions

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-[[Image:3ffl.png|left|200px]]
-<!--
+==Crystal Structure of the N-terminal Domain of Anaphase-Promoting Complex Subunit 7==
-The line below this paragraph, containing "STRUCTURE_3ffl", creates the "Structure Box" on the page.
+<StructureSection load='3ffl' size='340' side='right'caption='[[3ffl]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ffl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FFL FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ffl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffl OCA], [https://pdbe.org/3ffl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ffl RCSB], [https://www.ebi.ac.uk/pdbsum/3ffl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffl ProSAT]</span></td></tr>
-{{STRUCTURE_3ffl|  PDB=3ffl  |  SCENE=  }}
+</table>
+== Function ==
-===Crystal Structure of the N-terminal Domain of Anaphase-Promoting Complex Subunit 7===
+[https://www.uniprot.org/uniprot/APC7_HUMAN APC7_HUMAN] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:18485873</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-<!--
+Check<jmol>
-The line below this paragraph, {{ABSTRACT_PUBMED_019091741}}, adds the Publication Abstract to the page
+  <jmolCheckbox>
-(as it appears on PubMed at http://www.pubmed.gov), where 019091741 is the PubMed ID number.
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ffl_consurf.spt"</scriptWhenChecked>
--->
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-{{ABSTRACT_PUBMED_019091741}}
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==About this Structure==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ffl ConSurf].
-[[3ffl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFL OCA].
+<div style="clear:both"></div>
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:019091741</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Han, D.]]
+[[Category: Large Structures]]
-[[Category: Kim, K.]]
+[[Category: Han D]]
-[[Category: Kim, Y.]]
+[[Category: Kim K]]
-[[Category: Cell cycle]]
+[[Category: Kim Y]]
-[[Category: Cell division]]
-[[Category: Helis-turn-helix]]
-[[Category: Mitosis]]
-[[Category: Tetratricopeptide repeat motif]]
-[[Category: Tpr repeat]]
-[[Category: Ubl conjugation pathway]]