2yuy: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:


==Solution Structure of PDZ domain of Rho GTPase Activating Protein 21==
==Solution Structure of PDZ domain of Rho GTPase Activating Protein 21==
<StructureSection load='2yuy' size='340' side='right' caption='[[2yuy]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2yuy' size='340' side='right'caption='[[2yuy]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2yuy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YUY FirstGlance]. <br>
<table><tr><td colspan='2'>[[2yuy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YUY FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARHGAP21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yuy OCA], [http://pdbe.org/2yuy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yuy RCSB], [http://www.ebi.ac.uk/pdbsum/2yuy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yuy ProSAT], [http://www.topsan.org/Proteins/RSGI/2yuy TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yuy OCA], [https://pdbe.org/2yuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yuy RCSB], [https://www.ebi.ac.uk/pdbsum/2yuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yuy ProSAT], [https://www.topsan.org/Proteins/RSGI/2yuy TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RHG21_HUMAN RHG21_HUMAN]] Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.<ref>PMID:15793564</ref> <ref>PMID:16184169</ref>
[https://www.uniprot.org/uniprot/RHG21_HUMAN RHG21_HUMAN] Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.<ref>PMID:15793564</ref> <ref>PMID:16184169</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 21: Line 21:


==See Also==
==See Also==
*[[Rho GTPase activating protein|Rho GTPase activating protein]]
*[[Rho GTPase activating protein 3D structures|Rho GTPase activating protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Inoue, M]]
[[Category: Large Structures]]
[[Category: Kigawa, T]]
[[Category: Inoue M]]
[[Category: Koshiba, S]]
[[Category: Kigawa T]]
[[Category: Niraula, T N]]
[[Category: Koshiba S]]
[[Category: Structural genomic]]
[[Category: Niraula TN]]
[[Category: Yokoyama, S]]
[[Category: Yokoyama S]]
[[Category: Yoneyama, M]]
[[Category: Yoneyama M]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Pdz domain]]
[[Category: Rho gtpase activating protein 21]]
[[Category: Rsgi]]
[[Category: Signaling protein]]

Latest revision as of 22:19, 29 May 2024

Solution Structure of PDZ domain of Rho GTPase Activating Protein 21Solution Structure of PDZ domain of Rho GTPase Activating Protein 21

Structural highlights

2yuy is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

RHG21_HUMAN Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Dubois T, Paleotti O, Mironov AA, Fraisier V, Stradal TE, De Matteis MA, Franco M, Chavrier P. Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics. Nat Cell Biol. 2005 Apr;7(4):353-64. Epub 2005 Mar 27. PMID:15793564 doi:http://dx.doi.org/10.1038/ncb1244
  2. ↑ Sousa S, Cabanes D, Archambaud C, Colland F, Lemichez E, Popoff M, Boisson-Dupuis S, Gouin E, Lecuit M, Legrain P, Cossart P. ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion. Nat Cell Biol. 2005 Oct;7(10):954-60. Epub 2005 Sep 25. PMID:16184169 doi:http://dx.doi.org/ncb1308
Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2yuy&oldid=4174448"