2ys2: Difference between revisions

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-[[Image:2ys2.jpg|left|200px]]<br /><applet load="2ys2" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2ys2" />
-'''Solution structure of the BTK motif of human Cytoplasmic tyrosine-protein kinase BMX'''<br />
-==About this Structure==
+==Solution structure of the BTK motif of human Cytoplasmic tyrosine-protein kinase BMX==
-YS2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YS2 OCA].
+<StructureSection load='2ys2' size='340' side='right'caption='[[2ys2]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2ys2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YS2 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ys2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ys2 OCA], [https://pdbe.org/2ys2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ys2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ys2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ys2 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ys2 TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BMX_HUMAN BMX_HUMAN] Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.<ref>PMID:9520419</ref> <ref>PMID:10688651</ref> <ref>PMID:11331870</ref> <ref>PMID:12370298</ref> <ref>PMID:12832404</ref> <ref>PMID:15788485</ref> <ref>PMID:18292575</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ys/2ys2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ys2 ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Non-specific protein-tyrosine kinase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Abe H]]
-[[Category: Abe, H.]]
+[[Category: Inoue M]]
-[[Category: Inoue, M.]]
+[[Category: Kigawa T]]
-[[Category: Kigawa, T.]]
+[[Category: Koshiba S]]
-[[Category: Koshiba, S.]]
+[[Category: Tochio N]]
-[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
+[[Category: Tomizawa T]]
-[[Category: Tochio, N.]]
+[[Category: Yokoyama S]]
-[[Category: Tomizawa, T.]]
+[[Category: Yoneyama M]]
-[[Category: Yokoyama, S.]]
-[[Category: Yoneyama, M.]]
-[[Category: ZN]]
-[[Category: bone marrow tyrosine kinase gene in chromosome x protein]]
-[[Category: epithelial and endothelial tyrosine kinase]]
-[[Category: etk]]
-[[Category: national project on protein structural and functional analyses]]
-[[Category: nppsfa]]
-[[Category: ntk38]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: structural genomics]]
-[[Category: transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:02:39 2008''