2yrq: Difference between revisions

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-[[Image:2yrq.jpg|left|200px]]
-<!--
+==Solution structure of the tandem HMG box domain from Human High mobility group protein B1==
-The line below this paragraph, containing "STRUCTURE_2yrq", creates the "Structure Box" on the page.
+<StructureSection load='2yrq' size='340' side='right'caption='[[2yrq]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2yrq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YRQ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yrq OCA], [https://pdbe.org/2yrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yrq RCSB], [https://www.ebi.ac.uk/pdbsum/2yrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yrq ProSAT], [https://www.topsan.org/Proteins/RSGI/2yrq TOPSAN]</span></td></tr>
-{{STRUCTURE_2yrq|  PDB=2yrq  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HMGB1_HUMAN HMGB1_HUMAN] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yr/2yrq_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yrq ConSurf].
+<div style="clear:both"></div>
-'''Solution structure of the tandem HMG box domain from Human High mobility group protein B1'''
+==See Also==
+*[[High mobility group protein|High mobility group protein]]
+__TOC__
-==About this Structure==
+</StructureSection>
-YRQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRQ OCA].
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Harada, T.]]
+[[Category: Harada T]]
-[[Category: Kigawa, T.]]
+[[Category: Kigawa T]]
-[[Category: Koshiba, S.]]
+[[Category: Koshiba S]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Tomizawa T]]
-[[Category: Tomizawa, T.]]
+[[Category: Watanabe S]]
-[[Category: Watanabe, S.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
-[[Category: Dna binding]]
-[[Category: Dna binding protein]]
-[[Category: Helix-turn-helix motif]]
-[[Category: Hmg box domain]]
-[[Category: National project on protein structural and functional analyse]]
-[[Category: Nppsfa]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 19:16:23 2008''