2krb: Difference between revisions
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==Solution structure of EIF3B-RRM bound to EIF3J peptide== | |||
<StructureSection load='2krb' size='340' side='right'caption='[[2krb]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2krb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KRB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2krb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2krb OCA], [https://pdbe.org/2krb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2krb RCSB], [https://www.ebi.ac.uk/pdbsum/2krb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2krb ProSAT]</span></td></tr> | |||
== | </table> | ||
[[2krb]] is a 2 chain structure with sequence from [ | == Function == | ||
[https://www.uniprot.org/uniprot/EIF3B_HUMAN EIF3B_HUMAN] Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.<ref>PMID:9388245</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kr/2krb_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2krb ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Eukaryotic initiation factor|Eukaryotic initiation factor]] | *[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Elantak | [[Category: Large Structures]] | ||
[[Category: Herrmannova | [[Category: Elantak L]] | ||
[[Category: Janoskova | [[Category: Herrmannova A]] | ||
[[Category: Lukavsky | [[Category: Janoskova M]] | ||
[[Category: Rutkai | [[Category: Lukavsky PJ]] | ||
[[Category: Valasek | [[Category: Rutkai E]] | ||
[[Category: Wagner | [[Category: Valasek L]] | ||
[[Category: Wagner S]] | |||