2kkc: Difference between revisions

<StructureSection load='2kkc' size='340' side='right'caption='[[2kkc]]' scene=''>

<table><tr><td colspan='2'>[[2kkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KKC FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kkc OCA], [https://pdbe.org/2kkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kkc RCSB], [https://www.ebi.ac.uk/pdbsum/2kkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kkc ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/SQSTM_RAT SQSTM_RAT] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Isoform 1 is more potent than isoform 2 to stimulate PRKCZ-dependent phosphorylation of KCNAB2.<ref>PMID:10477520</ref> <ref>PMID:11244088</ref> <ref>PMID:11500922</ref>  

[[Category: Large Structures]]

[[Category: Rattus norvegicus]]

[[Category: Inagaki F]]

[[Category: Yokochi M]]