2kby: Difference between revisions
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==The Tetramerization Domain of Human p73== | ==The Tetramerization Domain of Human p73== | ||
<StructureSection load='2kby' size='340' side='right'caption='[[2kby | <StructureSection load='2kby' size='340' side='right'caption='[[2kby]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2kby]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2kby]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBY FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kby OCA], [https://pdbe.org/2kby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kby RCSB], [https://www.ebi.ac.uk/pdbsum/2kby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kby ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kby OCA], [https://pdbe.org/2kby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kby RCSB], [https://www.ebi.ac.uk/pdbsum/2kby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kby ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Coutandin | [[Category: Coutandin D]] | ||
[[Category: Doetsch | [[Category: Doetsch V]] | ||
[[Category: Guntert | [[Category: Guntert P]] | ||
[[Category: Ikeya | [[Category: Ikeya T]] | ||
[[Category: Loehr | [[Category: Loehr F]] | ||
[[Category: Ou | [[Category: Ou HD]] | ||