2k2r: Difference between revisions
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==The NMR structure of alpha-parvin CH2/paxillin LD1 complex== | ==The NMR structure of alpha-parvin CH2/paxillin LD1 complex== | ||
<StructureSection load='2k2r' size='340' side='right' caption='[[2k2r | <StructureSection load='2k2r' size='340' side='right'caption='[[2k2r]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2k2r]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2k2r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K2R FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2r OCA], [https://pdbe.org/2k2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k2r RCSB], [https://www.ebi.ac.uk/pdbsum/2k2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PARVA_HUMAN PARVA_HUMAN] Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.<ref>PMID:11331308</ref> <ref>PMID:11134073</ref> <ref>PMID:15284246</ref> <ref>PMID:20393563</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[ | *[[Parvin 3D structures|Parvin 3D structures]] | ||
*[[Paxillin|Paxillin]] | *[[Paxillin|Paxillin]] | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Byeon | [[Category: Large Structures]] | ||
[[Category: Fukuda | [[Category: Byeon I]] | ||
[[Category: Gronenborn | [[Category: Fukuda K]] | ||
[[Category: Qin | [[Category: Gronenborn A]] | ||
[[Category: Velyvis | [[Category: Qin J]] | ||
[[Category: Wang | [[Category: Velyvis A]] | ||
[[Category: Wu | [[Category: Wang X]] | ||
[[Category: Wu C]] | |||