2k18: Difference between revisions

<StructureSection load='2k18' size='340' side='right'caption='[[2k18]]' scene=''>

<table><tr><td colspan='2'>[[2k18]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K18 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k18 OCA], [https://pdbe.org/2k18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k18 RCSB], [https://www.ebi.ac.uk/pdbsum/2k18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k18 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PDIA1_HUMAN PDIA1_HUMAN] This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.<ref>PMID:10636893</ref> <ref>PMID:12485997</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k1/2k18_consurf.spt"</scriptWhenChecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k18 ConSurf].

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Dabrowski C]]

[[Category: Denisov AY]]

[[Category: Gehring K]]

[[Category: Kozlov G]]

[[Category: Maattanen P]]

[[Category: Thomas DY]]