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==Determination of a Protein Structure in the Solid State from NMR Chemical Shifts== | ==Determination of a Protein Structure in the Solid State from NMR Chemical Shifts== | ||
<StructureSection load='2k0p' size='340' side='right'caption='[[2k0p | <StructureSection load='2k0p' size='340' side='right'caption='[[2k0p]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2k0p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_sp. | <table><tr><td colspan='2'>[[2k0p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_sp._'group_G' Streptococcus sp. 'group G']. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K0P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K0P FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k0p OCA], [https://pdbe.org/2k0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k0p RCSB], [https://www.ebi.ac.uk/pdbsum/2k0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k0p ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k0p OCA], [https://pdbe.org/2k0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k0p RCSB], [https://www.ebi.ac.uk/pdbsum/2k0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k0p ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/SPG1_STRSG SPG1_STRSG] Binds to the constant Fc region of IgG with high affinity. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 37: | Line 36: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Streptococcus sp. group | [[Category: Streptococcus sp. 'group G']] | ||
[[Category: Cavalli | [[Category: Cavalli A]] | ||
[[Category: Robustelli | [[Category: Robustelli P]] | ||
[[Category: Salvatella | [[Category: Salvatella X]] | ||
[[Category: Vendruscolo | [[Category: Vendruscolo M]] | ||
Latest revision as of 22:08, 29 May 2024
Determination of a Protein Structure in the Solid State from NMR Chemical ShiftsDetermination of a Protein Structure in the Solid State from NMR Chemical Shifts
Structural highlights
FunctionSPG1_STRSG Binds to the constant Fc region of IgG with high affinity. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedSolid-state NMR spectroscopy does not require proteins to form crystalline or soluble samples and can thus be applied under a variety of conditions, including precipitates, gels, and microcrystals. It has recently been shown that NMR chemical shifts can be used to determine the structures of the native states of proteins in solution. By considering the cases of two proteins, GB1 and SH3, we provide an initial demonstration here that this type of approach can be extended to the use of solid-state NMR chemical shifts to obtain protein structures in the solid state without the need for measuring interatomic distances. Determination of protein structures in the solid state from NMR chemical shifts.,Robustelli P, Cavalli A, Vendruscolo M Structure. 2008 Dec 10;16(12):1764-9. PMID:19081052[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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