2jzk: Difference between revisions

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-[[Image:2jzk.jpg|left|200px]]
-<!--
+==Structure of TbCVNH (T. BORCHII CVNH)==
-The line below this paragraph, containing "STRUCTURE_2jzk", creates the "Structure Box" on the page.
+<StructureSection load='2jzk' size='340' side='right'caption='[[2jzk]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2jzk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tuber_borchii Tuber borchii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JZK FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzk OCA], [https://pdbe.org/2jzk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jzk RCSB], [https://www.ebi.ac.uk/pdbsum/2jzk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jzk ProSAT]</span></td></tr>
-{{STRUCTURE_2jzk|  PDB=2jzk  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CVNH_TUBBO CVNH_TUBBO] Mannose-binding lectin.<ref>PMID:18400178</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/2jzk_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jzk ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Solution structures for three members of the recently discovered cyanovirin-N (CV-N) homolog family of lectins have been determined. Cyanovirin-N homologs (CVNHs) from Tuber borchii, Ceratopteris richardii, and Neurospora crassa, representing each of the three phylogenetic groups, were selected. All proteins exhibit the same fold, and the overall structures resemble that of the founding member of the family, CV-N, albeit with noteworthy differences in loop conformation and detailed local structure. Since no data are available regarding the proteins' function or their natural ligands, extensive carbohydrate-binding studies were conducted. We delineated ligand-binding sites on all three proteins by nuclear magnetic resonance and identified which sugars interact by array screening. The number and location of binding sites vary for the three proteins, and different ligand specificities exist. Potential physiological roles for two family members, TbCVNH and NcCVNH, were probed in nutrition deprivation experiments that suggest a possible involvement of these proteins in lifestyle-related responses.
-'''Structure of TbCVNH (T. BORCHII CVNH) (CASP TARGET)'''
+The evolutionarily conserved family of cyanovirin-N homologs: structures and carbohydrate specificity.,Koharudin LM, Viscomi AR, Jee JG, Ottonello S, Gronenborn AM Structure. 2008 Apr;16(4):570-84. PMID:18400178<ref>PMID:18400178</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-==About this Structure==
+</div>
-JZK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Tuber_borchii Tuber borchii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZK OCA].
+<div class="pdbe-citations 2jzk" style="background-color:#fffaf0;"></div>
-[[Category: Single protein]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Tuber borchii]]
-[[Category: Gronenborn, A M.]]
+[[Category: Gronenborn AM]]
-[[Category: Jee, J.]]
+[[Category: Jee J]]
-[[Category: Koharudin, L M.I.]]
+[[Category: Koharudin LMI]]
-[[Category: Ottonello, S.]]
+[[Category: Ottonello S]]
-[[Category: Viscomi, A R.]]
+[[Category: Viscomi AR]]
-[[Category: Antiviral protein]]
-[[Category: Carbohydrate binding protein]]
-[[Category: Cvnh]]
-[[Category: Nmr]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:26:45 2008''