2jw8: Difference between revisions
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==Solution structure of stereo-array isotope labelled (SAIL) C-terminal dimerization domain of SARS coronavirus nucleocapsid protein== | ==Solution structure of stereo-array isotope labelled (SAIL) C-terminal dimerization domain of SARS coronavirus nucleocapsid protein== | ||
<StructureSection load='2jw8' size='340' side='right'caption='[[2jw8 | <StructureSection load='2jw8' size='340' side='right'caption='[[2jw8]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jw8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2jw8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JW8 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jw8 OCA], [https://pdbe.org/2jw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jw8 RCSB], [https://www.ebi.ac.uk/pdbsum/2jw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jw8 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jw8 OCA], [https://pdbe.org/2jw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jw8 RCSB], [https://www.ebi.ac.uk/pdbsum/2jw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jw8 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/NCAP_SARS NCAP_SARS] Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (PubMed:17210170). May modulate transforming growth factor-beta signaling by binding host SMAD3 (PubMed:18055455).[HAMAP-Rule:MF_04096]<ref>PMID:17210170</ref> <ref>PMID:18055455</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chang | [[Category: Severe acute respiratory syndrome-related coronavirus]] | ||
[[Category: Chang | [[Category: Chang C]] | ||
[[Category: Guntert | [[Category: Chang Y]] | ||
[[Category: Hsu | [[Category: Guntert P]] | ||
[[Category: Huang | [[Category: Hsu Y]] | ||
[[Category: Ikeya | [[Category: Huang T]] | ||
[[Category: Kainosho | [[Category: Ikeya T]] | ||
[[Category: Takeda | [[Category: Kainosho M]] | ||
[[Category: Takeda M]] | |||