2hm8: Difference between revisions
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==Solution Structure of the C-terminal MA-3 domain of Pdcd4== | ==Solution Structure of the C-terminal MA-3 domain of Pdcd4== | ||
<StructureSection load='2hm8' size='340' side='right' caption='[[2hm8 | <StructureSection load='2hm8' size='340' side='right'caption='[[2hm8]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2hm8]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2hm8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HM8 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hm8 OCA], [https://pdbe.org/2hm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hm8 RCSB], [https://www.ebi.ac.uk/pdbsum/2hm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hm8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE] Note=Decreases benign tumor development and malignant progression. | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.<ref>PMID:12482958</ref> <ref>PMID:12894233</ref> <ref>PMID:16024603</ref> <ref>PMID:17060447</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Cell death protein|Cell death protein]] | *[[Cell death protein 3D structures|Cell death protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Bohm | [[Category: Mus musculus]] | ||
[[Category: Carr | [[Category: Bohm M]] | ||
[[Category: Choong | [[Category: Carr MD]] | ||
[[Category: Klempnauer | [[Category: Choong PT]] | ||
[[Category: Muskett | [[Category: Klempnauer KH]] | ||
[[Category: Veverka | [[Category: Muskett FW]] | ||
[[Category: Waters | [[Category: Veverka V]] | ||
[[Category: Waters LC]] | |||