2hde: Difference between revisions

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-{{Seed}}
-[[Image:2hde.png|left|200px]]
-<!--
+==Solution Structure of Human SAP18==
-The line below this paragraph, containing "STRUCTURE_2hde", creates the "Structure Box" on the page.
+<StructureSection load='2hde' size='340' side='right'caption='[[2hde]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2hde]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HDE FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hde OCA], [https://pdbe.org/2hde PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hde RCSB], [https://www.ebi.ac.uk/pdbsum/2hde PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hde ProSAT]</span></td></tr>
-{{STRUCTURE_2hde|  PDB=2hde  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SAP18_HUMAN SAP18_HUMAN] Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.<ref>PMID:9150135</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hd/2hde_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hde ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Signal transduction pathways are frequently found to repress transcription of target genes in the absence of stimulation and, conversely, to upregulate transcription in the presence of a signal. Transcription factors are central in this dual regulatory mechanism and widely use a generalized mechanism to repress transcription through recruitment of a Sin3-histone deacetylase (HDAC) complex to their binding sites on DNA. The protein SAP18 (Sin3-associated polypeptide of 18 kDa) has been shown to play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid. The solution structure of SAP18 reveals a ubiquitin-like fold with several large loop insertions relative to other family members. This fold supports the functional role of SAP18 as a protein-protein adapter module and provides insight for how SAP18 may bridge the Sin3-HDAC complex to transcription factors.
-===Solution Structure of Human SAP18===
+Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly.,McCallum SA, Bazan JF, Merchant M, Yin J, Pan B, de Sauvage FJ, Fairbrother WJ Biochemistry. 2006 Oct 3;45(39):11974-82. PMID:17002296<ref>PMID:17002296</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2hde" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_17002296}}, adds the Publication Abstract to the page
+*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 17002296 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_17002296}}
+__TOC__
+</StructureSection>
-==About this Structure==
-HDE is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDE OCA].
-==Reference==
-<ref group="xtra">PMID:17002296</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Fairbrother, W J.]]
+[[Category: Large Structures]]
-[[Category: McCallum, S A.]]
+[[Category: Fairbrother WJ]]
-[[Category: Pan, B.]]
+[[Category: McCallum SA]]
-[[Category: Yin, J P.]]
+[[Category: Pan B]]
-[[Category: Bicoid]]
+[[Category: Yin JP]]
-[[Category: Gaga]]
-[[Category: Gli]]
-[[Category: Hdac]]
-[[Category: Histone deacetylase]]
-[[Category: Sin3]]
-[[Category: Transcriptional repressor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:26:18 2009''